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Bioanalytical method development and validation for the pharmacokinetics and biodistribution study of pirfenidone-loaded solid lipid nanoparticles

Suci Ananda Putri, Yahdiana Harahap, Silvia Surini

DOI: 10.7324/JAPS.2026.231524

Red rice bran extract attenuates oxidative stress and testicular damage in high-fat diet/streptozotocin-induced diabetic rats

Watcharaporn Preedapirom Jeefoo, Atcharaporn Ontawong, Sirinat Pengnet, Tichanon Promsrisuk, Napapan Kangwan, Wathita Phachonpai, Arnon Pudgerd

DOI: 10.7324/JAPS.2026.249609

Discovery of pyrazole–pyrazoline derivatives as VEGFR-2 kinase inhibitors: In silico approach

Deepali M. Wanode, Kumud P. Bhendarkar, Pramod B. Khedekar

DOI: 10.7324/JAPS.2026.256031

Quinazolinone derivatives as selective COX-2 inhibitors: In silico analysis using molecular docking, dynamics, and ADMET

Tendy Oktriawan, Tri Joko Raharjo, Winarto Haryadi, Muhammad Idham Darussalam Mardjan

DOI: 10.7324/JAPS.2026.235134

Immunogenicity evaluation of an Alum-adjuvanted recombinant prefusion RBD-Fd SARS-CoV-2 protein subunit produced in Glycoengineered Pichia pastoris

Andri Wardiana, Hariyatun Hariyatun, Dian Fitria Agustiyanti, Yana Rubiyana, Alfi Taufik Fathurahman, Herjuno Ari Nugroho, Endah Puji Septisetyani, Popi Hadi Wisnuwardhani, Sugiyono Saputra, A’liyatur Rosyidah, Syaiful Rizal, Hastuti Handayani S. Purba, Kartika Sari Dewi, Nissa Arifa, Ratih Asmana Ningrum, Wien Kusharyoto

DOI: 10.7324/JAPS.2026.270912

Metabolite profiling and bioactivity of Pogostemon cablin L. from North Konawe: GC-MS analysis, anti-inflammatory, and antinociceptive mechanisms via COX-2/cytokine inhibition

Adryan Fristiohady, Jafriati, Irvan Anwar, Rathapon Asasutjarit, Idin Sahidin, Sry Susanti, Lidya Agriningsih Haruna, La Ode Muh Julian Purnama, Hariana, Hutamy Viranda Rahman

DOI: 10.7324/JAPS.2026.268636

Synergistic modification of polyvinyl alcohol and natural phospholipids: Nanoliposomal carrier for Sonneratia caseolaris L. delivery and therapeutic care

Arman Suryani, Hilda Amie Shafira Istiqhfarin, Nurul Hidayah, Narendra Nazzun Nitisara, Andina Melly Aryanti, Raisya Ardana, Erza Ridha Kartika

DOI: 10.7324/JAPS.2025.243159

Challenges of using Artificial Intelligence (Natural Language Processing) tools for regulatory documentation

Harshada B. Pawar, Neelanshu, Gowri M. Bhat, Arun Srikanth, Pradeep M. Muragundi

DOI: 10.7324/JAPS.2026.267918

Hypoglycemic potential of Sargassum spp.: A review of bioactive compounds for diabetes management

Muhamad Firdaus, Ahmad Faris Priambodo

DOI: 10.7324/JAPS.2026.234652

Improving rifampicin stability in the presence of modified isoniazid across different pH environment

Sushruta S. Hakkimane, Santosh L. Gaonkar, Vishnu Prasad Shenoy, Bharath Raja Guru

DOI: 10.7324/JAPS.2025.242027

Gut microbiota as a key player in type 2 diabetes: Current perspectives

Sruthi Sethumadhavan, Saramma Mini Jacob, Monica Narendra Babu

DOI: 10.7324/JAPS.2026.267236

Traditional Vietnamese herbal remedies treatments for Gout: A comprehensive review of mechanisms, practical applications, and therapeutic potential

Hung Minh Hoang, Ling Yan Yong, Khang Hoang Au, Tuan Minh Pham, Van Anh Thi Pham, Thu Hien Thi Dang, Yong Xiang Gao

DOI: 10.7324/JAPS.2026.254687

Phytochemical and pharmacological profile of Aegle marmelos (L.) Correa: A comprehensive review of therapeutic potential, mechanisms of action, and translational relevance

Amitha Shetty, Lowel Fernandes, Devendranath Shambhavi, Manohar Mahadev, Akhilesh Dubey

DOI: 10.7324/JAPS.2026.273299

Microbial nanoparticles: biosynthesis and emerging roles in combating antimicrobial resistance

Alan Raj, Angel Treasa Alex, Venkatesh Kamath, Volety Mallikarjuna Subrahmanyam

DOI: 10.7324/JAPS.2026.244963

Histopathological and immunohistochemical evaluation of the impact of coconut shell-derived liquid smoke hydrogel on diabetic wound healing

Masfria Masfria, Henny Lucida, Yusni Atifah, Hafid Syahputra, Emil Salim, Clarissa Henry, Agnes Valencia, Irfan Syafti, Ardiansyah Selian

DOI: 10.7324/JAPS.2025.v15.i12.11

Exploring the market dynamics of complex generics in United States and India

Amatha Sreedevi, Vani Lakshmi Ramesh, Manthan D. Janodia, Praveen Kumar, Virendra S. Ligade

DOI: 10.7324/JAPS.2025.v15.i12.15

The crossroads of Amantadine from antiviral to neurotherapeutic: Bibliometric mapping of six decades of therapeutic evolution

Razan Naji, Ibrahim Albokhadaim, Yassir A. Almofti, Mohammed Al-Rasheed, Maryam Mahmoud, Mahmoud Kandeel

DOI: 10.7324/JAPS.2025.v15.i12.16

Development of a validated LC-ESI-MS/MS method for the quantification of tucatinib in plasma samples

Sunil Dattatray Pawar, Deepak D. Kayande, Kokila Pawar, Mazahar Farooqui, Anil Shankarwar, Amol Deshpande, Sunil Shankarwar

DOI: 10.7324/JAPS.2025.213916

Agitation-assisted extraction of total phenolic and flavonoid compounds from lanche leaves [Myrcianthes discolor (Kunth) McVaugh]: Influence of solvent ratio and its impact on antioxidant activity

Juan Ernesto Valdiviezo-Campos, Cinthya Stephany Neglia Cermeño, Segundo Guillermo Ruiz-Reyes

DOI: 10.7324/JAPS.2025.243158

Salacia oblonga aqueous root extract restores β-cell function in experimental diabetes via antioxidant effects and MAFA upregulation

Senthil Kumar Anbumani, Manickam Subramanian, Sharmila Aristotle, Prabhu Kaliyaperumal

DOI: 10.7324/JAPS.2025.264678

Pharmacogenomics for sustainable drug development: A narrative review of precision medicine, green chemistry, and multi-omics innovation

Kanagaraj Lakshmi, Balaji Nagarajan, Kumaraswamy Dabburu, Chittran Roy, Balasubramanian Shanthi, Gunamoni Das, Tamalika Chakraborty, Shamina Syed, Joshua Albert, Kannaiyan Suria Prabha

DOI: 10.7324/JAPS.2025.260740

Thermotropic liquid crystals for precision drug delivery and diagnostics: Molecular design, characterization, and clinical translation

Anjana A. Kailas, K.A. Abutwaibe, Poornima Bhagavath, Debanjan Bhattacharjee, Annamalai Rama, Induja Govindan, Thamizharasan Annadurai, Anup Naha

DOI: 10.7324/JAPS.2025.255035

Enhanced oral delivery of epigallocatechin gallate via expanding gastro-retentive films composed of chitosan and konjac glucomannan blends

Arnas Lakhiew, Rachanida Praparatana, Yaowaporn Sangsen, Ruedeekorn Wiwattanapatapee

DOI: 10.7324/JAPS.2025.251914

Evaluation of Leptospermum petersonii methanol and ethyl acetate crude extracts for antimetastatic and apoptotic effects against pancreatic and prostate cancer cells

Maria Matlou, Mpho Choene, Lesetja Motadi

DOI: 10.7324/JAPS.2025.v15.i12.12

In-silico studies of anti-tuberculosis drugs using advanced computational technique: A DFT, molecular docking, and QSAR analysis

Bhavana Panthi, Anwesh Pandey, Indra Sen Ram, Samiyara Begum, Suresh Kumar

DOI: 10.7324/JAPS.2025.v15.i12.13

Regulation of estrogen receptor-mediated apoptosis by vitexin in human colorectal carcinoma cells

Surekha Vani, Bhagavathy Sivathanu

DOI: 10.7324/JAPS.2025.261688

Ethanolic root extract of Bouea macrophylla Griffith improves lipid homeostasis in palmitate-induced lipid accumulation in HepG2 cells

Linda Chularojmontri, Jarinyaporn Naowaboot, Urarat Nanna, Kusuma Jitsaeng, Thaweesak Juengwatanatrakul, Suvara Wattanapitayakul, Wanwisa Suwannaloet

DOI: 10.7324/JAPS.2025.250674

Mechanistic insights into the anti-aging potential of Centella asiatica via network pharmacology and molecular docking

Cut Shafa Safira, Raymond Rubianto Tjandrawinata, Adi Yulandi

DOI: 10.7324/JAPS.2025.240042

Biological prospecting of endophytic fungi from the stem bark of Oroxylum indicum (L.) Kurz with antioxidant efficacy

Sushma, Apoorva Kenjar, Juliet Roshini Mohan Raj, Vishakh Radhakrishna Kedilaya, Tamizh Selvan Gnanasekaran, Pavan Gollapalli, Sharmila Kameyanda Poonacha

DOI: 10.7324/JAPS.2025.247093

Identification of thiazolidin-4-one scaffold-based molecules as PI3Kα inhibitors: Molecular docking, MM/GBSA, IFD, ADMET, water-map analysis, and MD simulations

Keezhe Perumpadappu Krishnan, Kasaragod Mangala Shenoy, Suvarna Ganesh Kini, Ramaiah Selladurai Jeyaprakash

DOI: 10.7324/JAPS.2025.253482

Formulation development and optimization of nanoemulsion gel containing Prosopis cineraria, Aerva javanica, and Fagonia indica extracts for treatment of arthritis

Suman Jain, Abhishek Pandey

DOI: 10.7324/JAPS.2025.241266

Supercritical fluid extraction, LC-MS profiling, and QbD-guided green HPLC method for standardization of Careya arborea Roxb. nanoemulsion

Abhijit S. Salokhe, Archana S. Patil, Yadishma Gaude, Pooja Rayanade, Rahul Koli, Namdeo S. Jadhav

DOI: 10.7324/JAPS.2025.266427

Antihyperglycemic and hypoglycemic activities of Castanopsis costata: An experimental study with in vitro, in vivo, and histopathological evaluation

Maulana Yusuf Alkandahri, Asman Sadino, Wilda Fhitriany Usman, Eva Feriadi, Zulpakor Oktoba, Atri Sri Ulandari, Ana Yulyana, Annis Fathurrohmah, Shofa Khairunnisa, Indah Sari Amanatun Nisa, Annisa Rizqya Salmaduri

DOI: 10.7324/JAPS.2025.264681

Preformulation study as a basis for the development of Streptomyces sp. PNM-9 microparticles for biological control

Juan Ricardo Urrego, José David Tordecilla, Freddy Alejandro Ramos, Leonardo Castellanos, Carlos Alberto Bernal, Claudia Milena Baena-Aristizábal

DOI: 10.7324/JAPS.2025.257753

An ethnobotanical study of Indonesian medicinal plants to treat obesity

Devi Safrina, Nur Rahmawati Wijaya, Dian Susanti, M. Bakti Samsu Adi, Aditya Dwi Permana Putra, Sri Sulasmi, Rizal Maarif Rukmana, Pujiati Pujiati, Harto Widodo

DOI: 10.7324/JAPS.2025.229638

Network pharmacology and molecular dynamics studies unveil the therapeutic mechanisms of Zingiber officinale against dyspepsia

Stefeny Theresia Simatupang, Doni Dermawan, Nadia, Santi Tan, Raymond Rubianto Tjandrawinata

DOI: 10.7324/JAPS.2025.240961

Phytochemical and pharmacological aspects of the genus Chamaecrista: a systematic review

Domitila Villalba, Melissa Escobar, Cinthia Cazal Martínez, Javier E. Barúa, Fillipe De Oliveira Pereira, Juliana Moura-Mendes

DOI: 10.7324/JAPS.2025.241066

Medication reconciliation and its essentiality in the geriatric population: A comprehensive review

Abubakar Siddique Mustafa Hussain, Syed Azhar Syed Sulaiman, Safiya Fatima Khan, Waad Alrohily, Siti Maisharah Sheikh Ghadzi, Saud Mohammad Alsahali, Yaser Mohammed Al Worafi

DOI: 10.7324/JAPS.2025.235827

Development and evaluation of a proniosomal gel for palm tocotrienol-rich fraction topical delivery

Tanya Tong-en Fong, Puxvadee Chaiku, Kar Lin Nyam, Chee Chin Chu

DOI: 10.7324/JAPS.2025.v15.i12.6

In vitro assessment of α-glucosidase inhibitory activity and compound prediction in Phyllanthus niruri from West Java Indonesia

Idah Rosidah, Alfan Danny Arbianto, Firdayani Firdayani, Agus Supriyono, Kurnia Agustini, Ngatinem Ngatinem, Sri Ningsih

DOI: 10.7324/JAPS.2025.v15.i12.19

Optimization using response surface methodology and analysis of antimicrobial activity of pink pigmented Fusarium foetens CBS 110286

Bashir Ahmad Aliyu, Shashank Garg, Sawinder Kaur, Ashish Vyas

DOI: 10.7324/JAPS.2025.260601

Antioxidation, antiglycation, and cytoprotective potential of various kratom (Mitragyna speciosa) leaf extracts and its major alkaloid, mitragynine

Rinnapat Boonsut, Juraithip Wungsintaweekul, Charoenwong Premprasert, Narumon Sengnon, Ilham Hama, Supattra Limsuwanchote

DOI: 10.7324/JAPS.2025.v15.i12.21

Towards a drug distributor price reference index: A 2023 survey of pricing discrepancies for region 02 medicines procured from NCR and local distributors, Philippines

Jinky Marie Tuliao Chua, Julius Tamayao Capili, Ma. Angelita Saquing Rabanal, Lily Ann Caldez Mallabo, Jay Emmanuel Laciste Asuncion

DOI: 10.7324/JAPS.2025.v15.i12.5

Anti-inflammatory potential of Indonesian marine sponge Theonella sp.: Mechanisms via TNF-α, IL-6, and IL-12 inhibition

Adryan Fristiohady, Idin Sahidin, Taifo Mahmud, La Ode Muh Julian Purnama, Rathapon Asasutjarit, Fadhliyah Malik, Agung W.M. Yodha, Lidya Agriningsih Haruna, Arfan Arfan, Wahyuni Wahyuni

DOI: 10.7324/JAPS.2025.v15.i12.9

Investigation of extraction conditions for Oroxylum indicum root using ultrasound-assisted extraction and statistical design of experiments

Nanthawat Thongun, Orawan Monthakantirat, Chantana Boonyarat, Charinya Khamphukdee, Yaowared Chulikhit, Supawadee Daodee

DOI: 10.7324/JAPS.2025.v15.i12.17

Fabrication and characterization of chitosan–gelatin–chondroitin sulfate-diclofenac scaffold with cross-linked glutaraldehyde for potential application in osteoarthritis

Wa Ode Nurfinti, Chrismawan Ardianto, Toetik Aryani, Mareta Rindang Andarsari, Anisa Cendekia Muslimah, Ita Pramudia Ananta, Yusuf Alif Pratama, Nour El Huda Abd Rahim, Sakinato Mazidda, Esti Hendradi, Junaidi Khotib, Fani Deapsari, Aniek Setiya Budiatin

DOI: 10.7324/JAPS.2025.v15.i12.8

Triphala, Trikatu, and Benjakul: an evidence-based review of their pharmacology, toxicology, and clinical potential in integrative medicine

Soiphet Net-Anong, Arisara Phuwajaroanpong, Walaiporn Plirat, Atthaphon Konyanee, Prapaporn Chaniad, Chuchard Punsawad

DOI: 10.7324/JAPS.2025.v15.i12.4

Angiotensin (1–7) attenuates rotenone-induced Parkinsonism via Mas receptor and Nrf2 pathway in rats

Poonam Bhadauriya, Ahsas Goyal, Vibhav Varshney

DOI: 10.7324/JAPS.2025.247748

Evaluation of the herbal formulation HPH-031508PP in mitigating complications associated with dengue in experimental studies

Mohammed Mukhram Azeemuddin, Madan Mittlekoppa Narendra, Onkaramurthy Mallappa, Raghavendra Pralhada Rao, Bindu Indira, Mohamed Rafiq, Hucharayappa Ganesh

DOI: 10.7324/JAPS.2025.227453

Wound healing potential of Adenium socotranum (Vierh.) leaf extract: Phytochemical profiling and molecular docking analysis

Ibrahim Ali Al-Hakami, Bushra Abdulkarim Moharram, Hassan M. AL-Mahbashi, Tareq Al Maqtari, Wafa M. Al-Madhagi

DOI: 10.7324/JAPS.2025.261427

Substandard and falsified pediatric medicines in low–middle-income countries: A narrative review on impacts and strategies

Shailee Dewan, Pradeep M. Muragundi, Vani Lakshmi Ramesh, Virendra S. Ligade, Dharmagadda Sreedhar, Adithya D. Shetty

DOI: 10.7324/JAPS.2025.246088

Isolation, identification, and antimicrobial evaluation of bioactive metabolites from Streptomyces geysiriensis against UTI associated bacterial strains

Mohamed A. El-Sakhawy, Amro Hanora, Mahmoud Mohamed Zaky, Abeer Ali El-Sherbiny Ateya, Heba S. Ibrahim, Roaa Amar Abdel Bast

DOI: 10.7324/JAPS.2025.250607

Chemistry, resources, anticancer effects, other pharmacological properties, and clinical trials of oleandrin from Nerium oleander: An overview

Siu Kuin Wong, Hung Tuck Chan, Eric Wei Chiang Chan

DOI: 10.7324/JAPS.2025.257922

Quantification of asciminib by LC-MS/MS method in human plasma: Validation and stability studies

Hema, Naresh Panigrahi

DOI: 10.7324/JAPS.2024.163326