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May, 2025

Volume: 15, Issue: 5

In this Issue: Corrigendum: 1, Research Article: 19, Review Article: 4
On the cover: Phytochemical compounds against mild cognitive impairment key proteins (Image Credit: Ruiz et al. Universidad Nacional Autónoma de México, Tlalnepantla, México).

5 Apr, 2025   Review Article

Betula utilis (Bhojpatra): A potent herb with its traditional uses, phytochemistry, clinical application, pharmacology, and toxicology

Aanchal Loshali, Garima Tripathi, Sandhya Bawa, Vidhu Aeri

DOI: 10.7324/JAPS.2025.230627Pages: 001-013

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5 Apr, 2025   Review Article

Acceptance and reluctance of COVID-19 vaccination among the general population: a systematic review and meta-analysis of cross-sectional studies

Gajalakshmi Thiyagarajan, Vanitha Rani Nagasubramanian, Seetha Lakshmi Ravichandran, Preetha Baskaran, Danya Cendhil Thangam, Rathiesh Kanna Sankaranarayanan, Krishna Undela, Bhima Sridevi, Ranakishor Pelluri, Prasada Chowdari Gurram, Jayaraman Rajangam

DOI: 10.7324/JAPS.2025.205927Pages: 014-023

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5 Apr, 2025   Review Article

Efficacy of nefopam in postoperative pain management: A systematic review of opioid consumption

Nagla Abdelmonim Bader, Mohammad M. Al-Ahmad, Waiel Al Naeem, Mohammed Gamal Amer

DOI: 10.7324/JAPS.2025.203223Pages: 024-039

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5 Apr, 2025   Review Article

Overcoming multifaceted challenges in cancer treatment: Targeting signal transduction pathways and tumor microenvironment for enhanced therapeutic efficacy

Abdul Majeed Ansari, Naresh Kumar Sharma, Kashinath Tripathi, Gautam Bhardwaj, Ritu Chauhan, Rajiv Kumar Tonk, Moyad Shahwan, Hardeep Singh Tuli, Abhishek Chauhan

DOI: 10.7324/JAPS.2025.204012Pages: 040-063

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5 Apr, 2025   Research Article

Triazole-based click chemistry as strategic for novel therapeutics treatments of cancer: A bibliometric analysis 2007–2024

Wilson Cardona-Galeano, Andres F. Yepes, Howard Ramírez-Malule

DOI: 10.7324/JAPS.2025.221899Pages: 064-074

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5 Apr, 2025   Research Article

The UHPLC-HRMS profiling, in vitro-antioxidant and pancreatic lipase inhibitory activities of Peronema canescens leaves extract and fractions from Indonesia

Ade Erma Suryani, Khoirun Nisa, Sri Handayani, Cici Darsih, Hastari Wuryastuty, Yanuartono Yanuartono

DOI: 10.7324/JAPS.2025.214965Pages: 075-089

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5 Apr, 2025   Research Article

Phytochemical compounds against mild cognitive impairment key proteins: An in-silico approach

Cristian Gonzalez-Ruiz, Isabel Hidalgo, Andrés Portilla-Martínez, Iván Rubio-Gayosso, Hermelinda Salgado-Ceballos, Omar Fabela-Sánchez, Jorge Bernal-Hernández, Miguel Ortiz-Flores

DOI: 10.7324/JAPS.2025.209505Pages: 090-101

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5 Apr, 2025   Research Article

Estrogenic effect, druglikeness, molecular docking, and pathway analysis of active compounds from fruit flour extract Rhizophora mucronata

Ernawati Ernawati, Moh Awaludin Adam, Sonny Kristianto, Taufan H. Sugara, Maftuch Maftuch, Fahrurrozi Fahrurrozi, Irawati Mei Widiastuti

DOI: 10.7324/JAPS.2025.203140Pages: 102-111

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5 Apr, 2025   Research Article

Establishment and validation of LC-MS/MS technique for Lenacapavir quantification in rat plasma, with application to pharmacokinetic assessment

Edward Raju Gope, Srikanth Pottendla, Suneetha Yaparthi

DOI: 10.7324/JAPS.2025.229006Pages: 112-120

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5 Apr, 2025   Research Article

Active fraction of Ciplukan (Physalis angulata L.) increases phosphorylation on IRS-1 Tyr-612 and Akt Ser-473 in 24-hour incubation time

Felicia Beta Papilaya, Mae Sri Hartati Wahyuningsih, Rul Afiyah Syarif

DOI: 10.7324/JAPS.2025.225043Pages: 121-128

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5 Apr, 2025   Research Article

Development of pentagamavunon-1 complexes with glycated albumin for targeted drug delivery: Synthesis, characterization, and cytotoxicity in cancer cells

Fea Prihapsara, Edy Meiyanto, Khadijah, Anif Nur Artanti, Adam Hermawan

DOI: 10.7324/JAPS.2025.221096Pages: 129-137

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5 Apr, 2025   Research Article

Rapid screening of adipogenic responses to EGCG in non-induced L929 adipocytes using image-based analysis compared to the conventional 3T3-L1 method

Kewalin Inthanon, Rungnapa Sririwichitchai, Neal M. Davies

DOI: 10.7324/JAPS.2025.220047Pages: 138-148

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5 Apr, 2025   Research Article

Evaluating the association between blood types and COVID-19 infection: A retrospective investigation carried out in the Northern Emirates of United Arab Emirates

Manjunatha Goud, Manal Mahmoud Sami Mohammed Abdelghani, Laxminarayana Kurady Bairy, Ashika Anu John, Jenibel Leela Rex Pancras Prabu, Anisha Sridhar, Tarig Hakim Merghani Hakim, Sathvik Belagodu Sridhar, Javedh Shareef

DOI: 10.7324/JAPS.2025.221468Pages: 149-155

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5 Apr, 2025   Research Article

Therapeutic drug monitoring of tacrolimus in kidney transplant patients: Insights from an Indian tertiary care clinical setting

Chaitra Rao Karkal, Daksha Dineshchandra Shetty, Sara Hajizadeh Amzajerdi, Tejashree Pasumarthi, Shankar Prasad Nagaraju, Ravindra Attur Prabhu, Surulivelrajan Mallayasamy

DOI: 10.7324/JAPS.2025.211306Pages: 156-162

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5 Apr, 2025   Research Article

Subchronic toxicological evaluation of the Holothuria atra extract on the histopathology of digestive organs of rats (Rattus norvegicus)

Muhammad Nursid, Endar Marraskuranto, Ariyanti S. Dewi, Gintung Patantis, Tiara Silva Khatulistiani, Yann Yeo, Sri Estuningsih

DOI: 10.7324/JAPS.2025.216477Pages: 163-175

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5 Apr, 2025   Research Article

Investigation ethanol extract of Piper crocatum leaves as condyloma acuminata inhibitor using protein interaction and molecular simulation

Idrianti Idrus, Wresti Indriatmi, Rasiha Rasiha, Fadilah Fadilah

DOI: 10.7324/JAPS.2025.203484Pages: 176-188

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5 Apr, 2025   Research Article

Development and validation of a bioanalytical RP-HPLC method for quantification of ifenprodil in rat plasma

Pavani Bonagiri, Narender Malothu, Srilakshmi Nallapaty, Chakravarthi Guntupalli

DOI: 10.7324/JAPS.2025.180823Pages: 189-196

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5 Apr, 2025   Research Article

Wound healing activity of herbal ointment containing ethanol leaves extracts of Memecylon species collected from a part of the Eastern Ghats Regions

Ratna Manjula R, Thirumal M

DOI: 10.7324/JAPS.2025.227377Pages: 197-204

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5 Apr, 2025   Research Article

Investigating the anti-cancer activity of cardanol a component of cashew nut shell liquid in oral cancer using in silico analysis

Vishal Jadhav, Anuj Maini, Vaibhav Sunil Ladke

DOI: 10.7324/JAPS.2025.215258Pages: 205-216

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5 Apr, 2025   Research Article

Development of spectrophotometric methods for simultaneous determination of Diltiazem and Naringin

Anju Chettri, Bhupendra Shrestha

DOI: 10.7324/JAPS.2025.159183Pages: 217-222

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11 Mar, 2025   Research Article

An experimental investigation evaluating the protective effect of a hydroalcoholic extract of the aerial portion of Alenda (Ephedra fragilis Desf.) against hepatotoxicity caused by mercaptopurine in rats

Afaf H. Al-Nadaf, Nisreen Abu Shahin, Areej Awadallaha, Raghd Obidat, Samia Arman, Samar Thiab

DOI: 10.7324/JAPS.2025.907107Pages: 223-231

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5 Apr, 2025   Research Article

Screening of factors influencing amoxicillin biodegradation by Aspergillus tamarii using fractional factorial design

Muhammad Zafri Zamri, Muhammad Naziz Saat, Muhammad Asyraf Mohamad Kamil, Zaidah Zainal Ariffin

DOI: 10.7324/JAPS.2025.192932Pages: 232-241

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5 Apr, 2025   Research Article

Development and application of an LC-MS/MS method for the detection of N-nitrosochlordiazepoxide as a potential genotoxic impurity

Srinivas Birudukota, Bhaskar Mangalapu, Ramesha Andagar Ramakrishna, Swagata Halder

DOI: 10.7324/JAPS.2025.199616Pages: 242-253

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5 Apr, 2025   Corrigendum

Corrigendum to “De novo designed lactoferrin–oleic acid-loaded chitosan nanoparticles with improved activity and selectivity toward four human cancer cells as compared to conventional complexes”

DOI: 10.7324/JAPS.2025.110307.corrigendumPages: 254-256