Betula utilis D. Don, (B.utilis) commonly known as the Himalayan silver birch or Bhojpatra, is a long-lived member of the Betulaceae family and grows in the subalpine zones of the Himalayan region at elevations ranging from 2,700 to 4,500 m. This species of Betula genus holds significant value in traditional and folk medicine, particularly in Ayurvedic medicine, where its bark has been used to cure various illnesses, such as blood and ear infections, pneumonia, convulsions, skin ailments, and many more. Phytochemical investigations reveal that B. utilis is abundant in triterpenoids, flavonoids, phenols, vitamins, and essential oils, among other compounds. Pharmacologically, the species exhibits a wide range of activities, including anti-inflammatory, antimicrobial, anticancer, hepatoprotective, anti-psoriatic, anti-obesity, anti-urolithiasis, anticonvulsant, anti-HIV, and antioxidant properties. This study summarizes research on the botanical taxonomy, phytochemistry, pharmacological properties, and ethnomedicinal uses, of B. utilis that was published between 1968 and 2024. Furthermore, toxicological studies are also discussed to provide insights into the safety profile of this species, an essential consideration for its therapeutic applications. To retrieve literature, search engines, including PubMed, Scopus, and Google Scholar, were used. This comprehensive review provides detailed information on the traditional uses, phytochemical composition, pharmacological activity, and toxicological aspects of B. utilis by integrating traditional knowledge with current findings. These reviews aim to serve as a valuable resource for researchers to guide future investigations.
Loshali A, Tripathi G, Bawa S, Aeri V. Betula utilis (Bhojpatra): A potent herb with its traditional uses, phytochemistry, clinical application, pharmacology, and toxicology. J Appl Pharm Sci. 2025. Online First. http://doi.org/10.7324/JAPS.2025.205927
1. World Health Organization. General guidelines for methodologies on research and evaluation of traditional medicine. Geneva, Switzerland: World Health Organization; 2000.
2. Chattergee A, Pakrashi SC. Introduction In: The treatise on Indian medicinal plants. New Delhi, India: CSIR; 1992.
3. Das M, Barua N. Pharmacological activities of Solanum melongena Linn.(Brinjal plant). Int J Green Pharm. 2013;7(4):274–7. doi:
4. Zobel DB, Singh SP. Himalayan forests and ecological generalizations. BioScience. 1997;47(11):735–45. doi: https://doi.org/10.2307/1313096
5. Dasila K, Pandey A, Samant SS, Pande V. Endophytes associated with Himalayan silver birch (Betula utilis D. Don) roots in relation to season and soil parameters. Appl Soil Ecol. 2020;149:103513. doi: https://doi.org/10.1016/j.apsoil.2020.103513
6. Bhattacharyya A, Shah SK, Chaudhary V. Would tree ring data of Betula utilis be potential for the analysis of Himalayan glacial fluctuations. Curr Sci. 2006;25:754–61.
7. Kala CP. Uses, population status and management of Betula utilis. Appl Ecol Environ Res. 2018;6(3):79–83. doi: https://doi.org/10.12691/aees-6-3-2
8. Verma D, Ajgaonkar S, Sahu N, Rane M, Teli N. Pharmacological and phytochemical properties of Betula utilis: an overview. Res J Pharm Biol Chem Sci. 2014;5(5):284–8.
9. Joshi H, Saxena GK, Singh V, Arya E, Singh RP. Phytochemical investigation, isolation and characterization of betulin from bark of Betula utilis. J Pharmacogn Phytochem. 2013;2(1):145–51.
10. Hooker JD. The flora of British India. London, UK: L. Reeve; 1890.
11. Wani ZA, Pant S. Betula utilis D. Don: an ecologically and economically important timberline species of Himalayan Region in Jeopardy. Bot Rev. 2021;87(3):377–91. doi: https://doi.org/10.1007/s12229-021-09259-x
12. The Ayurvedic Pharmacopoeia. National Institute of Science Communication and Information Resources (NISCAIR), New Delhi, India: Pharmacopoeia Commission for Indian Medicine & Homoeopathy, Ministry of AYUSH, Government of India, 2016.
13. Chauhan NS. Medicinal and aromatic plants of Himachal Pradesh. New Delhi, India: Indus Publishes; 1999.
14. Kumaraswamy MV, Kavitha HU, Satish S. Antibacterial evaluation and phytochemical analysis of Betula utilis D. Don against some human pathogenic bacteria. World J Agric Sci. 2008;4(5):661–4.
15. Rastogi RP, Mehrotra BN 2004. Indian medicinal plants: compendium of indian medicinal plants. Niscair. 2004;1:57.
16. Maletha A, Maikhuri RK, Bargali SS. Criteria and indicator for assessing threat on Himalayan birch (B. utilis) at timberline ecotone of Nanda Devi Biosphere Reserve: a world heritage site, Western Himalaya, India. Environ Sustain Indic. 2020;8:100086. doi: https://doi.org/10.1016/j.indic.2020.100086
17. Shaw K, Roy S, Wilson B. Betula utilis. The IUCN Red list of threatened species 2014:e.T194535A2346136. [cited 2023 Oct 04]. doi:
18. Moerman D. Native American Ethnobotany.1st edition. Portland, OR: Timber Press; 1998. pp 1098.
19. Singla C, Ali M. Antidandruff activity and chemical constituents of the leaves of Betula cylindrostachya Lindl. ex Wall. J Med Plants Stud. 2018;6(4):18993.
20. Harlow WM, Harrar ES. Textbook of dendrology 5th edition. New York City, NY: McGraw Hill Book Company; 1969.
21. Woods KE, Chhetri BK, Jones CD, Goel N, Setzer WN. Bioactivities and compositions of Betula nigra essential oils. J Med Plant. 2013;2(1-2):1–9. doi: https://doi.org/10.7275/R5639MP8
22. Murphy BJ, Carlson RE, Howa JD, Wilson TM, Buch RM. Determining the authenticity of methyl salicylate in Gaultheria procumbens L. and Betula lenta L. essential oils using isotope ratio mass spectrometry. J Essent Oil Res. 2021;33(5):442–51.
23. Saric-Kundalic B, Dobes C, Klatte-Asselmeyer V, Saukel J. Ethnobotanical study on medicinal use of wild and cultivated plants in middle, south and west Bosnia and Herzegovina. J Ethnopharmacol. 2010;131(1):33–55. doi: https://doi.org/10.1016/j.jep.2010.05.061
24. Kim H, Song MJ. Analysis and recordings of orally transmitted knowledge about medicinal plants in the southern mountainous region of Korea. J Ethnopharmacol. 2011;134(3):676–96. doi: https://doi.org/10.1016/j.jep.2011.01.024
25. Malhi BS, Trivedi VP. Vegetable antifertility drugs of India. Int J Crude Drug Res. 1972;12(3):1922–8. doi: https://doi.org/10.3109/13880207209068244
26. Quality standards of Indian medicinal plants. Medicinal plants unit Indian council of medical research, New Delhi, India: ICMR; 2012.
27. Phondani PC. A study on prioritization and categorization of specific ailments in different high altitude tribal and non-tribal communities and their traditional plant based treatments in Central Himalaya. Unpublished Ph. D. Thesis submitted to HNB Garhwal Central University, Srinagar (Garhwal) Uttarakhand, India. 2010.
28. Sharma N. Conservation and utilization of medicinal and aromatic plants in Dhauladhar mountain range of Himachal Pradesh. Ph.D. Thesis. Forest Research Institute (Deemed University), Dehradun, India: 2017.
29. Selvam A. Inventory of vegetable crude drug samples housed in botanical survey of India, Howrah. Pharmacogn Rev. 2008;2(3):61.
30. Jain SK. Dictionary of Indian folk medicine and ethnobotany. 1991.
31. Anonymous. The Wealth of India: Raw Materials. National Institute of Science Communication and Information Resources (NISCAIR), New Delhi, India: Publications and Information Directorate, CSIR; 1989.
32. Khan N, Ahmed M, Ahmed A, Shaukat SS, Wahab M, Ajaib M, et al. Important medicinal plants of chitral gol National park (cgnp) Pakistan. Pak J Bot. 2011;2:797–809.
33. Zaki M, Sofi MS, Kaloo ZA. A reproducible protocol for raising clonal plants from leaf segments excised from mature trees of Betula utilis a threatened tree species of Kashmir Himalayas. Int J Adv Multidiscip Res. 2011;1(5):07–13.
34. Khanday AL, Buhroo AA. Shothole borer (Scolytus nitidus Schedl) (Coleoptera: Curculionidae: Scolytinae): a new host-Himalayan birch (Betula utilis)-Short Communication. Nat Sci. 2015;13:15–26.
35. Mir NA, Masoodi TH, Geelani SM, Wani AA, Parrey GN, Mugloo JA. Floristic diversity along altitudinal gradient under Betula utilis in North Western Himalayas of Kashmir, India. Acta Ecologica Sinica. 2019;39(5):362–71. doi: https://doi.org/10.1016/j.chnaes.2019.03.001
36. Dawadi B, Liang E, Tian L, Devkota LP, Yao T. Pre-monsoon precipitation signal in tree rings of timberline Betula utilis in the central Himalayas. Quat Int. 2013;283:72–7. doi: https://doi.org/10.1016/j.quaint.2012.05.039
37. Manandhar NP. Plants and people of Nepal. Portland, OR: Timber Press; 2002.
38. Jäger S, Trojan H, Kopp T, Laszczyk MN, Scheffler A. Pentacyclic triterpene distribution in various plants–rich sources for a new group of multi-potent plant extracts. Molecules. 2009;14(6):2016–31. doi:
39. Shukla S, Mishra T, Pal M, Meena B, Rana TS, Upreti DK. Comparative analysis of fatty acids and antioxidant activity of Betula utilis bark collected from different geographical region of India. Free Radic Antioxid. 2017;7(1):80–5. doi: https://doi.org/10.5530/fra.2017.1.12
40. Pal M, Mishra T, Kumar A, Baleshwar, Upreti DK, Rana TS. Chemical constituents and antimicrobial potential of essential oil from Betula utilis growing in high altitude of Himalaya (India) J Essent Oil-Bear Plants. 2015;18(5):1078–82. doi:
41. Rajbhandari KR. Ethnobotany of Nepal Ethnobotanical Society of Nepal. Kathmandu, Nepal: Ethnobotanical Society of Nepal; 2001.
42. Ghimire SK, Sapkota IB, Oli BR, Parajuli RR. Non-timber forest products of Nepal Himalaya: database of some important species found in the mountain protected areas and surrounding regions. Kathmandu, Nepal: WWF Nepal; 2008.
43. Gewali MB. Aspects of Traditional Medicine in Nepal. Toyama, Japan: Institute of Natural Medicine; 2008.
44. Baral SR, Kurmi P. A Compendium of Medicinal Plants in Nepal. Kathmandu, Nepal: Mass Printing Press; International Union for the Conservation of Nature and Natural Resources; 2006.
45. Shinwari ZK, Gilani SS. Sustainable harvest of medicinal plants at Bulashbar Nullah, Astore (northern Pakistan). J Ethnopharmacol. 2003;84(2-3):289–98. doi: https://doi.org/10.1016/S0378-8741(02)00333-1
46. Angmo K, Adhikari BS, Rawat GS. Changing aspects of traditional healthcare system in Western Ladakh, India. J Ethnopharmacol. 2012;143(2):621–30. doi: https://doi.org/10.1016/j.jep.2012.07.017
47. Mahmood A, Mahmood A, Malik RN. Indigenous knowledge of medicinal plants from Leepa valley, Azad Jammu and Kashmir, Pakistan. J Ethnopharmacol. 2012;143(1):338–46. doi: https://doi.org/10.1016/j.jep.2012.06.046
48. Malhotra CL, Balodi B. Wild medicinal plants in the use of Johari tribals. J Econ Taxon Bot. 1984;5:841–3.
49. Chopra RN, Nayar SL, Chopra IC. Glossary of Indian medicinal plants (including the supplement). New Delhi, India: CSIR; 1986.
50. Negi KS, Tiwari JK, Gaur RD. Economic importance of some common trees in Garhwal Himalaya: an ethnobotanical study. Indian J For. 1985;8:276–89.
51. Khan MA. Karachic acid: a new triterpenoid from Betula utilis. Phytochem. 1975;14(3):789–91. doi: https://doi.org/10.1016/0031-9422(75)83036-6
52. Mishra T, Chandra P, Kumar B, Baleshwar M, Joshi P, Rana TS, et al. Phytochemical profiling of the stem bark of Betula utilis from different geographical regions of India using UHPLC-ESI-MS/MS. Anal Sci Adv T. 2021;11:497–504. doi: https://doi.org/10.1002/ansa.202000073
53. Fulda S. Betulinic acid for cancer treatment and prevention. Int J Mol Sci. 2008 Jun 27;9(6):1096–107. doi: https://doi.org/10.3390/ijms9061096
54. Jonnalagadda SC, Suman P, Morgan DC, Seay JN. Recent developments on the synthesis and applications of betulin and betulinic acid derivatives as therapeutic agents. Stud Nat Prod Chem. 2017;53:45–84. doi:
55. Amiri S, Dastghaib S, Ahmadi M, Mehrbod P, Khadem F, Behrouj H, et al. Betulin and its derivatives as novel compounds with different pharmacological effects. Biotechnol Adv. 2020;38:107409. doi: https://doi.org/10.1016/j.biotechadv.2019.06.008
56. Pal M, Mishra T, Kumar A, Baleshwar, Upreti DK, Rana TS. Characterization of fatty acids in the bark of Betula utilis growing in high altitudes of himalaya. Chem Nat Compd. 2015;51:326–7. doi:
57. Zdzisi?ska B, Szuster-Ciesielska AM, Rzeski W, Kanderfer-Szerszen M. Therapeutic properties of betulin and betulinic acid, components of birch bark extract. Farmaceutyczny Przeglad Naukowy. 2010;7(3):33–9.
58. Yogeeswari P, Sriram D. Betulinic acid and its derivatives: a review on their biological properties. Curr Med Chem. 2005;12(6):657–66. doi: https://doi.org/10.2174/0929867053202214
59. Markert B, Steinbeck R. Einige Aspekte der Elementverteilung in Betula alba, ein Beitrag zur repräsentativen Probenahme von terrestrischen Pflanzen für die Multielement-Analyse. Fresenius Z Anal Chem. 1988;331:616–9. doi: https://doi.org/10.1007/BF01032537
60. Shehzad MR, Hanif MA, Rehman R, Bhatti IA, Bhatta KR. Himalayan birch. In: Medicinal plants of South Asia. Elsevier 2020. pp 369–79.
61. Kuznetsova SA, Skvortsova GP, Maliar IN, Skurydina ES, Veselova OF. Extraction of betulin from birch bark and study of its physico-chemical and pharmacological properties. Russ. J Bioorganic Chem. 2014;40:742–7. doi: https://doi.org/10.1134/S1068162014070073
62. Šiman P, Filipová A, Tichá A, Niang M, Bezrouk A, Havelek R. Effective method of purification of betulin from birch bark: the importance of its purity for scientific and medicinal use. PLoS One. 2016;11(5):e0154933. doi: https://doi.org/10.1371/journal.pone.0154933
63. Tsepaeva OV, Nemtarev AV, Abdullin TI, Grigor’eva LR, Kuznetsova EV, Akhmadishina RA, et al. Design, synthesis, and cancer cell growth inhibitory activity of triphenylphosphonium derivatives of the triterpenoid betulin. J Nat Prod. 2017;80(8):2232–9. doi: https://doi.org/10.1021/acs.jnatprod.7b00105
64. Chrobak E, Jastrz?bska M, B?benek E, Kadela-Tomanek M, Marciniec K, Latocha M, et al. Molecular structure, in vitro anticancer study and molecular docking of new phosphate derivatives of betulin. Molecules. 2021 Jan 31;26(3):737. doi: https://doi.org/10.3390/molecules26030737
65. Wang J, Wu J, Han Y, Zhang J, Lin Y, Wang H, et al. Synthesis and biological evaluation of novel betulin derivatives with aromatic hydrazone side chain as potential anticancer agents. J Braz Chem Soc. 2022;33(03):227–37. doi: https://doi.org/10.21577/0103-5053.20210140
66. Bebenek E, Chodurek E, Orchel A, Dzieroewicz Z, Boryczka SL. Antiproliferative activity of novel acetylenic derivatives of betulin against g-361 human melanoma cells. Acta Pol Pharm. 2015;72(4):699–703.
67. Santos RC, Salvador JA, Marín S, Cascante M, Moreira JN, Dinis TC. Synthesis and structure–activity relationship study of novel cytotoxic carbamate and N-acylheterocyclic bearing derivatives of betulin and betulinic acid. Bioorg Med Chem. 2010;18(12):4385–96. doi: https://doi.org/10.1016/j.bmc.2010.04.085
68. Tang J, Jones SA, Jeffery JL, Miranda SR, Galardi CM, Irlbeck DM, et al. Synthesis and biological evaluation of macrocyclized betulin derivatives as a novel class of anti-HIV-1 maturation inhibitors. Open J Med Chem. 2014;8:23. doi: https://doi.org/10.2174/1874104501408010023
69. Csuk R. Targeting cancer by betulin and betulinic acid. In novel apoptotic regulators in carcinogenesis. Dordrecht, The Netherlands: Springer Netherlands; 2012. pp 267–87.
70. Rastogi S, Pandey MM, Rawat AK. Medicinal plants of the genus Betula—Traditional uses and a phytochemical–pharmacological review. J Ethnopharmacol. 2015;159:62–83. doi: https://doi.org/10.1016/j.jep.2014.11.010
71. Aiken C, Chen CH. Betulinic acid derivatives as HIV-1 antivirals. Trends Mol Med. 2005 Jan 1;11(1):31–6. doi: https://doi.org/10.1016/j.molmed.2004.11.001
72. Pandey KP, Chaturvedi G. Charak Samhita. Varanasi, India: Chaukhamba Bhartiya Academy; 2015.
73. Shastri AK. Sushruta chikitsa and Sushruta Kalpa. Vol-I. Varanasi, India: Chaukhamba Sanskrit Sansthana; 2017.
74. Gupta KSA. Astanga Hridya. Varanasi, India: Chaukhamba Sanskrit sansthana; 1980.
75. Shrikantamurthya KR. Astanga samgraha. Vol-II and Vol-III. Bengaluru, India: Chaukhamba Orientalia; 2005.
76. Tripathi I. Chakradatta Samhita. Varanasi, India: Chaukhamba Sanskrit Sansthana; 2005.
77. Shastri AK. Varanasi, India: Chaukhamba Sanskrit Sansthana; 2010.
78. Mishra T, Arya RK, Meena S, Joshi P, Pal M, Meena B, et al. Isolation, characterization and anticancer potential of cytotoxic triterpenes from Betula utilis bark. PLoS One. 2016;11(7):e0159430. doi: https://doi.org/10.1371/journal.pone.0159430
79. Singh S, Yadav S, Sharma P, Thapliyal A. Betula utilis: a potential herbal medicine. Int J Pharm Biol Arch. 2012;3(3):493-8.
80. Rackova L, Oblozinsky M, Kostalova D, Kettmann V, Bezakova L. Free radical scavenging activity and lipoxygenase inhibition of Mahonia aquifolium extract and isoquinoline alkaloids. J Inflamm. 2007;4(1):1-7. https://doi.org/10.1186/1476-9255-4-15
81. Kumaraswamy MV, Satish S. Free radical scavenging activity and lipoxygenase inhibition of Woodfordia fructicosa Kurz and Betula utilis Wall. Afr J Biotechnol. 2008;7(12):2013-6. https://doi.org/10.5897/AJB2008.000-5049
82. Sareen A, Ahirwar R, Gautam A, Bhadauria R. Fungal contamination of some common medicinal plant samples of Himachal Pradesh. Sci Cult. 2010;76:118-20.
83. Duraiswamy B, Satishkumar MN, Gupta S, Rawat M, Porwal O, Murugan R. Hepatoprotective activity of Betula Utilis bark on D-galactosamine induced hepatic insult. World J Pharm Pharma Sci. 2012;1:456-71.
84. Biswasroy P, Pradhan D, Sahu DK, Rai V, Halder J, Rajwar TK, et al. Phytochemical investigation, structural elucidation, in silico study and anti-psoriatic activity of potent bioactive from Betula utilis. J Biomol Struct Dyn. 2023;41(17):8093-108. doi: https://doi.org/10.1080/07391102.2022.2130981
85. VS A, Satish S, Shabaraya AR. Effect of Betula utilis bark extract on cafeteria diet-induced obesity in rats. European J Biomed Pharm Sci. 2019;6(5):441-5.
86. Goyal A, Kaur R, Sharma D, Sharma M. Protective effect of Betula utilis bark extract on high fat diet induced obesity in Wistar rats. Obes Med. 2019;15:100123. doi: https://doi.org/10.1016/j.obmed.2019.100123
87. Shah SK, Patel KM, Vaviya PM. Evaluation of antiurolithiatic activity of Betula utilis in rats using ethylene glycol model. Asian J Pharm Res Dev. 2017;7(2):81-7. https://doi.org/10.5958/2231-5691.2017.00014.4
88. Patley C, Bhadhkariya S, Sahu K, Kohli S, Sagar R. Betula utilis D. don: study of anticonvulsant and anxiolytic agent. Eur J Biomed Pharm Sci. 2022;9:305-9.
89. Xu HX, Zeng FQ, Wan M, Sim KY. Anti-HIV triterpene acids from Geum japonicum. J Nat Prod. 1996;59(7):643-5. https://doi.org/10.1021/np960165e
90. Mayaux JF, Bousseau A, Pauwels R, Huet T, Henin Y, Dereu N, et al. Activation and inhibition of proteasomes by betulinic acid and its derivatives. Natl Acad Sci. 1994;91:3564. https://doi.org/10.1073/pnas.91.9.3564
91. Chaniad P, Sudsai T, Septama AW, Chukaew A, Tewtrakul S. Evaluation of anti-HIV-1 integrase and anti-inflammatory activities of compounds from Betula alnoides Buch-Ham. Adv Pharmacol Pharm Sci. 2019;1:2573965. https://doi.org/10.1155/2019/2573965
92. Bhat AM, Qureshi R, Yaseen M. Phytochemical investigation and antioxidant activity of methanolic extract of Betula Utilis Bark. J Pharm Innov. 2022;2(2):4-12. https://doi.org/10.36647/JPRI/02.02.A002
93. Sénéchal H, Geny S, Desvaux FX, Busson M, Mayera C, Arond Y, et al. Genetics and specific immune response in allergy to birch pollen and food: evidence of a strong, positive association between atopy and the HLA class II allele HLA-DR7. J Clin Immunol. 1991;104(2):395-401. https://doi.org/10.1016/S0091-6749(99)70384-2
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