Research Article | Volume: 2 Issue: 12, December, 2012

Synthesis, characterization, and biological applications of some 2-acetylpyridine and acetophenone derivatives

Nura Suleiman Gwaram,  Hapipah Mohd Ali,  Siti Munirah Saharin,  Mahmood Ameen Abdulla,  Pouya Hassandarvish,  Thong Kwai Lin,  Chai Lay Ching and Cher Lin Ooi   
Nura Suleiman Gwaram1, Hapipah Mohd Ali1, Siti Munirah Saharin1, Mahmood Ameen Abdulla2, Pouya Hassandarvish2, Thong Kwai Lin3, Chai Lay Ching3 and Cher Lin Ooi3

1Chemistry Department, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.

2Molecular Medicine Department, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.

3Institute of Biological Science Faculty of science, University of Malaya, 50603 Kuala Lumpur, Malaysia.

Open Access    DOI: 10.7324/JAPS.2012.21206

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Abstract

This paper comprises two series of complexes which showed different modes of coordination. The fist series involved an N,N',N''-donor Schiff base ligand from the reaction of 2-acetylpridine as carbonyl compound with N,N'-dimethylethylenediamine (L1), the second series involved N,N',O-donor Schiff base from the condensation reaction of 2-hydroxyacetophenone (ketone) as carbonyl compound with N,N'-dimethylethylenediamine (L2). The ligands and complexes were characterized by using melting point, elemental analysis, FT-IR, NMR, and UV/Visible spectroscopy. The complexes showed very low cytotoxicity towards MCF-7 breast cancer cell line. They also showed moderate zone inhibition against Gram positive bacterium Methicillin-resistant Staphylococcus aureus, Acinetobacter baumannii and Pseudomonas aeruginosa. No antimicrobial activity observed with Klebsiella pneumonia.


Keyword:     Schiff bases Complexes Anticancer MCF-7Antibacterial MRSA

Citation:

Nura Suleiman Gwaram, Hapipah Mohd Ali, Siti Munirah Saharin, Mahmood Ameen Abdulla, Pouya Hassandarvish, Thong Kwai Lin, Chai Lay Ching and Cher Lin Ooi., Synthesis, characterization, and biological applications of some 2- acetylpyridine and acetophenone derivatives. J App Pharm Sci. 2012; 2 (10): 027-038.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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