Two series of novel benzimidazole derivatives were synthesized. The first one comprise of 2-methyl, the second one comprise of 2-phenyl substitution on benzimidazole moiety. Seven novel benzimidazole derivatives were synthesized successfully in appreciable yields and characterized physicochemically. The structures of all the synthesized derivatives were confirmed by IR and 1HNMR. Furthermore, the synthesized compounds were screened for antimicrobial activity (antibacterial activity and antifungal activity) by tube dilution method. Some of the synthesized compounds showed appreciable antifungal activity.
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