Research Article | Volume : 1 Issue : 4, June 2011

Structure activity relationship studies of synthesised pyrazolone derivatives of imidazole, benzimidazole and benztriazole moiety for anti-inflammatory activity

Julee P. SoniDhrubo Jyoti Sen Kamal M. Modh   

Open Access   

Abstract

In the present investigation, a series of some synthesis and biological evaluation of some pyrazolone derivatives with imidazole, benzimidazole and benztriazole moiety were synthesized and tested for their anti-inflammatory activity in-vitro using celecoxib as a reference drug. Compound 8d was found to be the most potent derivative of the series with 75 %inhibition of inflammation.


Keyword:     Pyrazolone imidazole benzimidazole benztriazole %inhibition of inflammation.


Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

HTML Full Text

Reference

Article Metrics
483 Views 27 Downloads 510 Total

Year

Month

Related Search

By author names