Review Article | Volume: 11, Supplement 1, March, 2021

Pyrazolones as a potential anticancer scaffold: Recent trends and future perspectives

Suman Adhikari Manjinder Singh Pratibha Sharma Sandeep Arora   

Open Access   

Published:  Feb 11, 2021

DOI: 10.7324/JAPS.2021.11s103
Abstract

Cancers are already placing an enormous load on the worldwide healthcare practice; so, anti-neoplastic compounds nowadays are most essential in cancer remedy. Nevertheless, the expanding resistance in drug profiles’ appearance in recently available anticancer drugs has so far risen to a distressing level over past decades. Pyrazolone holds wideranging chemotherapeutic characteristics, including anticancer activity, and they inhabit a significant place in the novel drug development process. As per the literature, various hybridized pyrazolone moieties with different pharmacophores and pyrazolone metal complexes have anticancer activities with good potency. In recent years, pyrazolone hybrids and metal complexes were generated to study their anticancer properties. Out of these, some derivatives displayed promising strengths against the case of resistant and susceptible cell lines of cancer. This current review encloses the latest advances of pyrazolone hybrids including thiophene, aminomethylidenes , naphthoquinones, combretastatins, 2-substituted-4-(2-fluorophenoxy) pyridine, hydroxybenzo[a]phenazine, coumarin, dihydrobenzoxepine, cyclic peptide, cambinol derivatives of pyrazolone, and different metal complexes as a potential anticancer agent.


Keyword:     Anticancer agent pyrazolone metal complex cell line.


Citation:

Adhikari S, Singh M, Sharma P, Arora S. Pyrazolones as potential anticancer scaffold: Recent trends and future perspectives. J Appl Pharm Sci, 2021; 11 (Supp 1):026–037.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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