Research Article | Volume: 4, Issue: 10, October, 2014

Synthesis, characterization and anticancer studies of some morpholine derived Schiff bases and their metal complexes

Nura Suleiman Gwaram ,  Pouya Hassandarvish   
Nura Suleiman Gwaram1 & 2, Pouya Hassandarvish3

1Chemistry Department, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.

2Chemistry Department, Faculty of Natural and Applied Sciences, Umaru Musa Yar’adua University, P .M.B. 2218 Katsina, Nigeria.

3Molecular Medicine Department, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.

Open Access   

Published:  Oct 30, 2014

DOI: 10.7324/JAPS.2014.401014
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Abstract

This paper reported series of complexes and their modes of coordination. The series consist of N,N’,O-donor Schiff base formed by condensation reaction of 2-hydroxyacetophenone with 4-(2-aminoethyl)morpholine. The ligand and complexes were characterized by elemental analysis, FT-IR, NMR and UV/Visible spectroscopy. The complexes showed moderate cytotoxicity mediated on MCF-7 breast cancer cell line and were selective to some extent when compared to the WRL68 normal liver cell line.


Keyword:     Schiff bases metal complexes Anticancer MCF-7 WRL68.

Citation:

Nura Suleiman Gwaram, Pouya Hassandarvish. Synthesis, characterization and anticancer studies of some morpholine derived Schiff bases and their metal complexes. J App Pharm Sci, 2014; 4 (10): 075-080.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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