Research Article | Volume : 1 Issue : 4, June 2011

Isolation of Mucilage from Cydonia vulgaris Pers. Seeds and its Evaluation as Superdisintegrant

Nisarg C PatelVaishali N ShahAshok N Mahajan Dushyant A Shah   

Open Access   

Abstract

Gums and mucilages are preferably used as they are natural materials, for formulating conventional and novel dosage formulations. Natural materials have advantages over synthetic ones since they are chemically inert, nontoxic, less expensive, bio degradable and available in sufficient quantities. The study elaborates isolation of mucilage from the seeds of Cydonia vulgaris Pers. and explores it as tablet disintegrant. The mucilage was evaluated for all the parameters viz. solubility, swelling index, loss on drying, total ash, acid insoluble ash, microbial load and pH as per official monographs. The results confirmed that evaluation parameters were well within the limits. The disintegrating efficiency of isolated mucilage was equivalent to cross-povidone . The prepared batches were evaluated for hardness, friability, % drug content, wetting time, water absorption ratio and in vitro dispersion time. The results of isolated mucilage from Cydonia vulgaris Pers. were very promising.


Keyword:     Seed mucilage Cydonia vulgaris Pers. Fast disintegrating tablets Natural excipient.


Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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