Research Article | Volume: 2 Issue: 11, November, 2012

Three component one pot synthesis of 5-Substituted 1-Aryl-2,3-diphenyl imidazoles: A novel class of promising antioxidants

Nagaraja Naika H. Vijay Kumarb J. Rangaswamya S.T. Harinia and T.C. Umeshkumara   

Open Access    DOI: 10.7324/JAPS.2012.21112

Abstract

A novel series of structurally diverse 5-Substituted 1-Aryl-2,3-diphenyl imidazoles (2a-j) was synthesized by treatment of benzoin (1) with 4-hydroxy aniline, substituted benzaldehydes and NH4OAc in polyethylene glycol (PEG-400) under reflux condition in excellent yields. The newly synthesized compounds were characterized by spectral and elemental analysis and screened for their antioxidant properties by employing three in vitro assays like 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid (ABTS) assay and iron reducing power assay. Ascorbic acid was used as a standard antioxidant and the comparative study with newly synthesized compounds was also done. Among the analogues compounds 2e, 2g and 2j bearing hydroxy and methoxy groups on 2-substituted phenyl moiety respectively showed predominant antioxidant activity.


Keyword:     Benzoinsubstituted benzaldehydes5-Substituted 1-Aryl-23-diphenyl imidazolesantioxidant activity.


Citation:

Nagaraja Naik, H. Vijay Kumar, J. Rangaswamy, S.T. Harini, T.C. Umeshkumar, Three component one pot synthesis of 5-Substituted 1-Aryl-2,3-diphenyl imidazoles: A novel class of promising antioxidants. J App Pharm Sci. 2012; 2 (11): 067-074.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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