The trend of publication about Lumbricus rubellus for periodontitis treatment in the Scopus database: A bibliometric analysis

Lelly Andayasari Sagung Agung Putri Dwiastuti I Gusti Agung Ayu Dharmawati I Putu Suiraoka Heri Setiyo Bekti I Gusti Agung Ayu Putu Swastini Nurhayati Novia Susianti Iin Nurlinawati Made Ayu Lely Suratri Harimat Hendarwan Putu Sanna Yustiantara Eka Indra Setyawan   

Open Access   

Published:  May 24, 2024

DOI: 10.7324/JAPS.2024.179572

Periodontitis presents as a sustained deterioration of the periodontium, ultimately resulting in tooth loss. Lumbricus rubellus, a taxonomically recognized species commonly called the earthworm, is a significant component of natural constituents. This extraordinary organism exhibits intrinsic characteristics that confer antibacterial and anti-inflammatory capabilities. Nevertheless, it is essential to acknowledge that only a restricted subset of these pharmaceutical compounds has undergone meticulous scrutiny through clinical trials despite the potential effectiveness of L. rubellus in the treatment of periodontitis. The present investigation utilizes the Scopus database to conduct a bibliometric examination of the antioxidant characteristics of diverse strains of L. rubellus. This evaluation is performed through the utilization of the RStudio and VOSviewer applications. Consequently, 55 papers were encompassed within the ultimate bibliometric dataset. Moscow State University is widely acknowledged as a highly productive academic institution with significant global contributions. Mihara H is extensively acknowledged as the author with the highest level of productivity. The scholarly publication by Mihara et al. in 1991 significantly impacted the respective scientific discipline. These results provide insights to stimulate pharmaceutical research collaborations and reveal open issues about L. rubellus in the context of periodontitis therapy.

Keyword:     Antibacterial anti-inflammatory bibliometric Lumbricus rubellus periodontitis Scopus


Andayasari L, Dwiastuti SAP, Dharmawati IGAA, Suiraoka IP, Bekti HS, Swastini IGAAP, Nurhayati, Susianti N, Nurlinawati I, Suratri MAL, Hendarwan H, Yustiantara PS, Setyawan EI. The trend of publication about Lumbricus rubellus for periodontitis treatment in the Scopus database: A bibliometric analysis. J Appl Pharm Sci. 2024. Online First.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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1. Sun L, Du X, Kuang H, Sun H, Luo W, Yang C. Stem cell-based therapy in periodontal regeneration: a systematic review and meta-analysis of clinical studies. BMC Oral Health. 2023;23:1-13.

2. Huang X, Liu Y, Wang Q, Rehman HM, Horváth D, Zhou S, et al. Brief literature review and comprehensive bioinformatics analytics unravel the potential mechanism of curcumin in the treatment of periodontitis. BMC Oral Health. 2023;23:469.

3. Papapanou PN, Sanz M, Buduneli N, Dietrich T, Feres M, Fine DH, et al. Periodontitis: consensus report of workgroup 2 of the 2017 world workshop on the classification of periodontal and peri-implant diseases and conditions. J Periodontol. 2018;89:S173-82.

4. Pihlstrom BL, Michalowicz BS, Johnson NW. Periodontal diseases. Lancet. 2005;366:1809-20.

5. Phipps KR, Stevens VJ. Relative contribution of caries and periodontal disease in adult tooth loss for an HMO dental population. J Public Health Dent. 1995;55:250-2.

6. Van Dyke TE, Dave S. Risk factors for periodontitis. J Int Acad Periodontol. 2005;7:3-7.

7. Tomar SL, Asma S. Smoking-attributable periodontitis in the United States: findings from NHANES III. National Health and Nutrition Examination Survey. J Periodontol. 2000;71:743-51.

8. Preshaw PM, Alba AL, Herrera D, Jepsen S, Konstantinidis A, Makrilakis K, et al. Periodontitis and diabetes: a two-way relationship. Diabetologia. 2012;55:21-31.

9. Rocca JP, Fornaini C, Wang Z, Tan L, Merigo E. Focal infection and periodontitis: a narrative report and new possible approaches. Int J Microbiol. 2020;2020:8875612.

10. Hugoson A, Ljungquist B, Breivik T. The relationship of some negative events and psychological factors to periodontal disease in an adult Swedish population 50 to 80 years of age. J Clin Periodontol. 2002;29:247-53.

11. Pistorius A, Krahwinkel T, Willershausen B. Relationship between stress factors and periodontal disease. Eur J Med Res. 2002;7:393-8.

12. Wimmer G, Köhldorfer G, Mischak I, Lorenzoni M, Kallus KW. Coping with stress: its influence on periodontal therapy. J Periodontol. 2005;76:90-8.

13. Loos BG, Van Dyke TE. The role of inflammation and genetics in periodontal disease. Periodontol 2000. 2020;83:26-39.

14. Van Dyke TE, Serhan CN. Resolution of inflammation: a new paradigm for the pathogenesis of periodontal diseases. J Dent Res. 2003;82:82-90.

15. Wang CWJ, McCauley LK. Osteoporosis and periodontitis. Curr Osteoporos Rep. 2016;14:284-91.

16. Clark D, Kotronia E, Ramsay SE. Frailty, aging, and periodontal disease: basic biologic considerations. Periodontol 2000. 2021;87:143-56.

17. Deas DE, Mackey SA, McDonnell HT. Systemic disease and periodontitis: manifestations of neutrophil dysfunction. Periodontol 2000. 2003;32:82-104.

18. Slots J. Periodontitis: facts, fallacies and the future. Periodontol 2000. 2017;75:7-23.

19. Liu J, Ruan J, Weir MD, Ren K, Schneider A, Wang P, et al. Periodontal bone-ligament-cementum regeneration via Scaffolds and stem cells. Cells. 2019;8:537.

20. Dharmawati IGAA, Mahadewa TGB, Widyadharma IPE. Antibacterial activity of Lumbricus rubellus earthworm extract against Porphyromonas gingivalis as the bacterial cause of periodontitis. Open Access Maced J Med Sci. 2019;7:1032-6.

21. Mathur A, Kumar Verma S, Kumar Singh S, Prakash A, Prasad GBKS, Dua VK. Anti-inflammatory activity of earthworm extracts. Int J Pharm Sci Res. 2011;2:278-81.

22. Istiqomah L, Sofyan A, Damayanti E, Julendra H. Amino acid profile of earthworm and earthworm meal (Lumbricus rubellus) for animal feedstuff. J Indones Trop Anim Agric. 2009;34:253-7.

23. Tasiemski A. Antimicrobial peptides in annelids. Invertebr Surviv J. 2008;5:75-82.

24. Dewi NWS, Mahendra AN. The in-vivo anti-inflammatory effect of red earthworm (Lumbricus rubellus) ethanolic extract from organic farmland in Bali, Indonesia. Bali Med J. 2020;9:545-8.

25. Donthu N, Kumar S, Mukherjee D, Pandey N, Lim WM. How to conduct a bibliometric analysis: an overview and guidelines. J Bus Res. 2021;133:285-96.

26. Ellegaard O, Wallin JA. The bibliometric analysis of scholarly production: how great is the impact? Scientometrics. 2015;105:1809-31.

27. Fatimah SF, Lukitaningsih E, Martien R, Nugroho AK. Bibliometric analysis of articles on nanoemulsion and/or in-situ gel for ocular drug delivery system published during the 2011-2021 period. Pharmacia. 2022;69:467-84.

28. Lee IS, Lee H, Chen YH, Chae Y. Bibliometric analysis of research assessing the use of acupuncture bibliometric analysis of research assessing the use of acupuncture for pain treatment over the past 20 years. J Pain Res. 2020;13:367-76.

29. Župi? I, ?ater T. Bibliometric methods in management and organization. Organ Res Methods. 2015;18:429-72.

30. Dede E, Ozdemir E. Mapping and performance evaluation of mathematics education research in Turkey: a bibliometric analysis from 2005 to 2021. J Pedagog Res. 2022;6:1-19.

31. Abafe EA, Bahta YT, Jordaan H. Exploring biblioshiny for historical assessment of global research on sustainable use of water in agriculture. Sustainability. 2022;14:1-34.

32. Aksnes DW, Langfeldt L, Wouters P. Citations, citation indicators, and research quality: an overview of basic concepts and theories. Sage Open. 2019;9:1-17.

33. Kraus S, Filser M, O'Dwyer M, Shaw E. Social entrepreneurship: an exploratory citation analysis. Rev Manag Sci. 2014;8:275-92.

34. Shepeleva OA, Kodolova OP, Zhukovskaia EA, Striganova BR. Genetic diversity of populations of the earthworm Lumbricus rubellus (Hoffm.) (Oligochaeta, Lumbricidae). Biol Bull. 2008;35:170-7.

35. Zhang Q, Liu H, Zhang Y, Ruan H. The complete mitochondrial genome of Lumbricus rubellus (Oligochaeta, Lumbricidae) and its phylogenetic analysis. Mitochondrial DNA B Resour. 2019;4:2677-8.

36. Gao P, Meng F, Mata MN, Martins JM, Iqbal S, Correia AB, et al. Trends and future research in electronic marketing: a bibliometric analysis of twenty years. J Theor Appl Electron Commer Res. 2021;16:1667-79.

37. Thompson DF, Walker CK. A descriptive and historical review of bibliometrics with applications to medical sciences. Pharmacotherapy. 2015;35:551-9.

38. Mathankar AR. Bibliometrics: an overwiew. Int J Libr Inf Sci. 2018;7:9-15.

39. Kawamura M, Thomas CD, Tsurumoto A, Sasahara H, Kawaguchi Y. Lotka's law and productivity index of authors in a scientific journal. J Oral Sci. 2000;42:75-8.

40. Cooper EL, Hirabayashi K. Origin of innate immune responses: revelation of food and medicinal applications. J Tradit Complement Med. 2013;3:204-12.

41. Dewi NWS, Mahendra AN, Putra GWK, Jawi IM, Sukrama DM, Kartini NL. Ethanolic extract of the powder of red earthworm (Lumbricus rubellus) obtained from several organic farmlands in Bali, Indonesia: analysis of total phenolic content and antioxidant capacity. Bali Med J. 2017;3:S80-3.

42. Santangelo C, Varì R, Scazzocchio B, Di Benedetto R, Filesi C, Masella R. Polyphenols, intracellular signalling and inflammation. Ann Ist Super Sanita. 2007;43:394-405.

43. Luo W, Deng ZH, Li R, Cheng G, Kotian RN, Li YS, et al. Study of analgesic effect of earthworm extract. Biosci Rep. 2018;38:1-9.

44. Gan TJ. Diclofenac: an update on its mechanism of action and safety profile. Curr Med Res Opin. 2010;26:1715-31.

45. Arifah FH, Nugroho AE, Rohman A, Sujarwo W. A bibliometric analysis of preclinical trials of andrographis Paniculata (Burm.f.) nees in diabetes mellitus. S Afr J Bot. 2022;151:128-43.

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