Research Article | Volume: 7, Issue: 8, August, 2017

LC-ESI-MS profile, antioxidant activity and cytotoxic screening of Oligomeris linifolia (Vahl) Macbr. (Resedaceae)

Ali M. El-Hagrassy Ahmed Elkhateeb Sameh R. Hussein El-Sayed S. Abdel-Hameed Mona M. Marzouk   

Open Access   

Published:  Aug 30, 2017

DOI: 10.7324/JAPS.2017.70807
Abstract

LC-ESI-MS analysis was investigated for the n-butanol, methanol and water fractions of Oligomeris linifolia, which leads to the identification of twenty-one compounds, among them sixteen compounds were firstly reported from this plant and five compounds were identified previously. Butanol and methanol fractions showed higher antioxidant activity with IC50 values of 10.37μg/ml and 31.07μg/ml, respectively, compared with that of the standard; Trolox (33.55μg/ml) using DPPH method. However, water fraction showed lower activity (IC50: 91.86 μg/ml). The three fractions were also screened for their cytotoxicity and showed weak effect against HCT116, A549 and MCF7 at 100 mg/ml and no effect against HEPG2.


Keyword:     Oligomeris linifolia phenolics flavonoids LC-ESI-MS Antioxidant Cytotoxicity.


Citation:

El-Hagrassi AM, Elkhateeb A, Hussein SR, Abdel-Hameed ES, Marzouk MM. LC–ESI-MS profile, antioxidant activity and cytotoxic screening of Oligomeris linifolia (Vahl) Macbr. (Resedaceae). J App Pharm Sci, 2017; 7 (08): 043-047.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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