Research Article | Volume: 6, Issue: 4, April, 2016

Synthesis, antimicrobial evaluation and QSAR studies of N'-benzylidene/(1-phenylethylidene)undec-10-enehydrazides

Shashi Kumar Rakesh Narang Surendra Kumar Nayak Sachin Kumar Singh Balasubramanian Narasimhan   

Open Access   

Published:  Apr 30, 2016

DOI: 10.7324/JAPS.2016.60415
Abstract

A series of N'-benzylidene/(1-phenylethylidene)undec-10-enehydrazide was synthesized starting from undec-2-enoic acid through multi-step reactions. Synthesized derivatives were evaluated for their in vitro antimicrobial activities against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Aspergillus niger and Candida albicans by tube dilution method. The preliminary results showed the significance of o-NO2, m-NO2 and m-OCH3 groups at phenyl ring in describing antimicrobial activity of synthesized compounds. QSAR studies revealed that second order molecular connectivity index (2χ) and Balaban topological index (J) are the key parameters for antimicrobial activity of synthesized hydrazide derivatives and can be cosidered as important factors for interaction with target site of different microorganisms. It is pertinent to note that multi-target QSAR models were more significant in demonstrating the antimicrobial activity than one-target QSAR models.


Keyword:     Antifungal antibacterial undec-10-enoic acid hydrazide QSAR.


Citation:

Kumar S, Narang R, Nayak SK, Singh SK, Narasimhan B. Synthesis, antimicrobial evaluation and QSAR studies of N'- benzylidene/(1-phenylethylidene)undec-10-enehydrazides. J App Pharm Sci, 2016; 6 (04): 104-116.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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