Published:  Apr 30, 2016DOI: 10.7324/JAPS.2016.60415
A series of N'-benzylidene/(1-phenylethylidene)undec-10-enehydrazide was synthesized starting from undec-2-enoic acid through multi-step reactions. Synthesized derivatives were evaluated for their in vitro antimicrobial activities against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Aspergillus niger and Candida albicans by tube dilution method. The preliminary results showed the significance of o-NO2, m-NO2 and m-OCH3 groups at phenyl ring in describing antimicrobial activity of synthesized compounds. QSAR studies revealed that second order molecular connectivity index (2χ) and Balaban topological index (J) are the key parameters for antimicrobial activity of synthesized hydrazide derivatives and can be cosidered as important factors for interaction with target site of different microorganisms. It is pertinent to note that multi-target QSAR models were more significant in demonstrating the antimicrobial activity than one-target QSAR models.
Kumar S, Narang R, Nayak SK, Singh SK, Narasimhan B. Synthesis, antimicrobial evaluation and QSAR studies of N'- benzylidene/(1-phenylethylidene)undec-10-enehydrazides. J App Pharm Sci, 2016; 6 (04): 104-116.
357 Absract views 7 PDF Downloads 364 Total views
Synthesis and Antimicrobial studies of novel Benzimidazole derivatives
Synthesis and in-vitro Anti Tumor Activity of Some Novel 2, 3-Disubstituted Quinazolin 4(3H)-one Derivatives
Synthesis, molecular docking and QSAR studies of 2, 4-disubstituted thiazoles as antimicrobial agents