Research Article | Volume: 6, Issue: 4, April, 2016

Anticonvulsant and in vitro antioxidant activities of Momordica cissoides L. (Cucurbitaceae)

Lucie Josiane Ojong ,  Jean Pierre Abdou ,  Antoine KavayeKandeda ,  Abel Joel Gbaweng Yaya,  Armelle Deutou Tchamgoue,  Lauve Rachel Yamthe Tchokouaha,  Nadège Gisele Claudine Nkantchoua,  Gabriel Agbor Agbor,  Roger Somo Moyou,  Elisabeth Bum Ngo   
Lucie Josiane Ojong1 & 2, Jean Pierre Abdou3 & 4, Antoine KavayeKandeda2 & 5, Abel Joel Gbaweng Yaya3, Armelle Deutou Tchamgoue3, Lauve Rachel Yamthe Tchokouaha3, Nadège Gisele Claudine Nkantchoua2, Gabriel Agbor Agbor3, Roger Somo Moyou1, Elisabeth Bum Ngo2

1Center of Medical research, Institute of Medical research and Medicinal Plants Studies, P.O. Box: 6163, Yaoundé Cameroon.

2Department of Biological Sciences, Faculty of Science, University of Ngaoundéré, P.O. Box 454 Ngaoundéré Cameroon.

3Center for Research on Medicinal Plant and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies. P.O. Box 6163 Yaoundé-Cameroon.

4Department of Organic Chemistry, Faculty of Science, University of Yaoundé I P.O. Box 812, Yaoundé Cameroon.

5Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé-Cameroon.

6Institute of Mines and Petroleum Industries of Maroua, University of Maroua, P.O. Box 52, MarouaCameroon.

Open Access   

Published:  Apr 30, 2016

DOI: 10.7324/JAPS.2016.60416
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Abstract

The present study investigated the anticonvulsant effect of an herbal medicine candidate Momordica cissoides, by using two animal models of epilepsy; Pilocarpine-induced status epilepticus (SE) and seizures and the 4-aminopyridine-induced (4-AMP) seizures methods using albino mice. Four doses (425, 212.5, 106.25 and 42.5 mg/kg) of the plant extract were prepared and administered to four groups of mice respectively. for each group test M. cissoides protected 100% of mice at the doses 106.25 and 212.5 mg/kg and 80% at the doses of 42.5 and 425 mg/kg against generalized convulsions induced by pilocarpine (PILO) and 100% at the doses 106.25 and 212.5 mg/kg against tonic and clonic convulsions induced by 4-aminopyridine (4-AMP). Moreover, for the test of induction of convulsions by PILO, M. cissoides protected 100% of mice at doses 106.25 and 212.5 mg/kg and 80% at the doses of 42.5 and 425 mg/kg against death after 1 h and 24 h respectively. In addition, study evaluated the free radical scavenging of the decoction extracts of M. cissoides leaf in vitro. The antioxidant activity of M. cissoides were evaluated using the free radical scavenging activity assay (DPPH), total phenolic (TPC) and total flavonoids content (TFC) and ferric reducing antioxidant potential. Attained results show that the extract of M. cissoides leaf can be used in SE, generalized seizure, tonic and clonic seizures treatment. Moreover, the antiepileptic effect of this extract is probably caused by its antioxidant properties.


Keyword:     Anticonvulsant antioxidant status epilepticus Momordica Cissoides pilocarpine 4-aminopyridine.

Citation:

Ojong LJ, Abdou JP, Kandeda AK, Yaya AJG, Tchamgoue AD, Tchokouaha LRY, Nkantchoua NGC, Agbor GA, Moyou RS, Ngo EB. Anticonvulsant and in Vitro Antioxidant Activities of Momordica Cissoides L. (Cucurbitaceae). J App Pharm Sci, 2016; 6 (04): 117-123.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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