Research Article | Volume: 6, Issue: 4, April, 2016

Spectroscopic Investigations for Photo Stability of Diclofenac Sodium Complexed with Hydroxypropyl-β-Cyclodextrin

Alagumuthu Manikandan Shubhada Chandrasekhar Nemani V. Sadheeshkumar Sivakumar Arumugam   

Open Access   

Published:  Apr 30, 2016

DOI: 10.7324/JAPS.2016.60414
Abstract

Diclofenac sodium was complexed with hydroxypropyl-β-cyclodextrin and physicochemical characterization was performed to evaluate the photo stability of diclofenac sodium. X-ray powder diffraction, UV-Vis analysis and Fourier Transform Infrared Spectroscopy were performed to examine the changes if any in the morphology and the configuration of the complex. The photo stability test followed by High Performance Liquid Chromatography analysis of the complex was determined. In vitro anti-inflammatory test using Human Red Blood Cell membrane stabilization method and in vivo analgesic activity studies in rat models to evaluate the therapeutic potential assessment of the complexed and norml diclofenac sodium. The test results have proved that the complexed diclofenac with hydroxypropyl-β-cyclodextrin enhance the photodegradation rate and resolute the optimal molar ratio of diclofenac to hydroxypropyl-β-cyclodextrin as 1:4. In vitro anti-inflammatory activity and in vivo analgesic activity results are indicates that the complexed form of diclofenac sodium with hydroxypropyl-β-cyclodextrin does not affects the therapeutic potentials of the drug.


Keyword:     Photo stability Diclofenac Sodium hydroxypropyl-β-cyclodextrin Anti-inflammation analgesic activity.


Citation:

Manikandan A, Nemani SC, Sadheeshkumar V, Arumugam S. Spectroscopic Investigations for Photo Stability of Diclofenac Sodium Complexed with Hydroxypropyl-Β-Cyclodextrin. J App Pharm Sci, 2016; 6 (04): 098-103.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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