Research Article | Volume: 5, Issue: 3, March, 2015

Phytochemical screening and antidiabetic effect of extracts of the seeds of Citrullus lanatus in alloxan-induced diabetic albino mice

Umar Muhd Sani   

Open Access   

Published:  Mar 28, 2015

DOI: 10.7324/JAPS.2015.50309
Abstract

Diabetes mellitus is a major and current epidemic disease of the human race implicated with numerous clinical manifestations. A number of protein-rich seeds such as that of Citrullus lanatus (watermelon) are commonly used in traditional medicine with increasing acclaimed efficacy against diabetes mellitus. In this study the effects of petroleum ether and ethanol extracts of the seeds of Citrullus lanatus on blood glucose levels in alloxan-induced diabetes in mice have been investigated. Hyperglycemia was induced by the injection of 150 mg/kg (i.p.) of alloxan monohydrate freshly dissolved in physiological saline. Doses (150, 200 and 250 mg/kg) per os, of the extracts were separately administered to a group of five diabetic mice in the study. The activity was compared with reference standard glibenclamide (2 mg/kg, p.o.) and negative control of physiological saline. Treatment of alloxan-induced diabetic mice with the crude extracts of C. lanatus seeds brought down the raised blood glucose levels significantly (P


Keyword:     Alloxan monohydrateCitrullus lanatusdiabetes mellitusphysiological salineglibenclamidealbino mice.


Citation:

Umar Muhd Sani. Phytochemical Screening and Antidiabetic Effects of Extracts of the Seeds of Citrullus lanatus in Alloxaninduced Diabetic Albino Mice. J App Pharm Sci, 2015; 5 (03): 051- 054.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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