Research Article | Volume: 7, Issue: 3, March, 2017

Median lethal dose (LD50) and cytotoxicity of Adriamycin in female albino mice

Rehab M. Mosaad Amany Samir Hassan M. Ibrahim   

Open Access   

Published:  Mar 30, 2017

DOI: 10.7324/JAPS.2017.70312
Abstract

The median lethal dose of Adriamycin and its cytotoxicity in three vital organs (heart, liver and kidney) was studied. The median lethal dose (LD50) was 56.875mg/kg body. Weight (b.wt). High doses of Adriamycin induced significant increases in heart tissues enzymes (lactate dehydrogenase (LDH), alkaline phosphatase (ALP) and Creatine Kinase-MB isoenzyme (CKMB)). Hepatotoxicity appeared in significant increment in liver function enzymes (aspartate aminotransferase (AST) and Alanine aminotransferase (ALT) activities) and lipid profile (cholesterol and triglycerides) and significant reduction in total protein and albumin. Moreover, urea and creatinine have recorded significant increases in kidney tissues after interpretoneal administration of high doses of Adriamycin (100, 90 and 80 mg/kg b.wt.).


Keyword:     Median lethal dose cytotoxicity Adriamycin female albino mice.


Citation:

Mosaad RM, Samir A, Ibrahim HM. Median lethal dose (LD50) and cytotoxicity of Adriamycin in female albino mice. J App Pharm Sci, 2017; 7 (03): 077-080.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

HTML Full Text

Reference

Article Metrics
37 Absract views 75 Absract Downloads 112 Total
Related Search

By author names