Research Article | Volume: 2 Issue: 9, September, 2012

Possible Revival of Atrophied Islet Cells of the Pancreas by Vernonia amygdalina in Alloxan Induced Diabetic Rats

Josiah J. Sunday Nwangwu C. O. Spencer Omage Kingsley Abdulrahamon A. Akintola Nkwonta Binyelum and Aderoju O. Favour.   

Open Access    DOI: 10.7324/JAPS.2012.2925

Abstract

The Possible Revival of atrophied islet cells of the pancreas by Vernonia amygdalina in alloxan-induced diabetic rats was evaluated. Twenty rats were divided into five groups (1, 2, 3, 4 and 5) of four rats each. Group 1 rats were given only feed and distilled water (normal control) throughout the period of the experiment. Group 3, 4 and 5 rats were pretreated with 250mg/kg body weight of the extract for 7, 14 and 21 days respectively. Diabetes was induced in rats in group 2, 3, 4 and 5 with 150mg/kg of body weight of alloxan monohydrate. Group 2 rats were used as the experimental control. Fasting blood glucose of rats in all the groups were measured before and 72 hours after induction of diabetes. The rats were sacrificed after 72 hours and the pancreas was histopathologically analysed. The result showed a significantly high blood glucose level in group 2 rats indicating the diabetic state. The blood glucose level of rats in group 3 and 5 reduced significantly (p<0.05) when compared with the value of group 2 rats but not significantly different from group 1 value. Group 4 showed a significantly (p<0.05) high blood glucose level when compared with the base-line. The histopathology revealed atrophied islet of Langerhans in group 2 rats. Group 3 and 5, showed reviving islet cells and group 4 showed increased lymphoid follicles and neutrophills. The results suggest that the aqueous extract of V. amygdaliana has a protective effect against alloxan induced pancreatic damage and potential to revive damaged islet cells.


Keyword:     Islet cells Vernonia amygdalina Alloxan monohydrate Glucose Histopathology Glucometer


Citation:

Josiah J. Sunday, Nwangwu C. O. Spencer, Omage Kingsley, Abdulrahamon A. Akintola, Nkwonta Binyelum and Aderoju O. Favour. Possible Revival of Atrophied Islet Cells of the Pancreas by Vernonia amygdalina in Alloxan Induced Diabetic Rats. J App Pharm Sci. 2012; 2(9): 127-131.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

HTML Full Text

Reference

Article Metrics
348 Views 11 Downloads 359 Total

Year

Month

Related Search

By author names