Research Article | Volume: 5, Issue: 3, March, 2015

Bioactive triterpenoids, antimicrobial, antioxidant and cytotoxic activities of Eclipta prostrata Linn.

Rungrot Cherdtrakulkiat,  Somchai Boonpangrak,  Ratchanok Pingaew,  Supaluk Prachayasittikul,  Somsak Ruchirawat ,  Virapong Prachayasittikul   
Rungrot Cherdtrakulkiat1, Somchai Boonpangrak2, Ratchanok Pingaew3, Supaluk Prachayasittikul4, Somsak Ruchirawat5 6, Virapong Prachayasittikul1

1Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand.

2Center for Innovation Development and Technology Transfer, Faculty of Medical Technology,Mahidol University, Bangkok 10700, Thailand.

3Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok 10110, Thailand.

4Center of Data Mining and Biomedical Informatics, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand.

5Laboratory of Medicinal Chemistry, Chulabhorn Research Institute and Program in Chemical Biology, Chulabhorn Graduate Institute, Bangkok 10210, Thailand.

6Center of Excellence on Environmental Health and Toxicology, Commission on Higher Education (CHE), Ministry of Education, Thailand.

Open Access   

Published:  Mar 28, 2015

DOI: 10.7324/JAPS.2015.50308
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Abstract

Bioactive triterpenoids; 3-acetylaleuritolic acid, stigmasterol, a mixture of triterpenoids, fatty esters and aromatic components were isolated from the aerial parts of Eclipta prostrata by column chromatography. The plant extracts were investigated for their antimicrobial activity (agar dilution method) against twenty-eight strains of gram-positive and gram-negative bacteria, including diploid fungus. In addition, antioxidant and cytotoxic activities were also evaluated. The extracts and isolated fractions exhibited antimicrobial activity against Morexella catarrhalis, Corynebacterium diphtheriae NCTC 10356 and Streptococcus pyogenes with the MIC of 64 µg/mL including Saccharomyces cerevisiae ATCC 2601 (MIC 256 µg/mL). The ethyl acetate extract and isolated fractions displayed antioxidant effect. In addition, the plant extracts showed cytotoxic activity (ED50 > 100 µg/mL) toward HuCCA-1 and KB cells. The results demonstrate beneficial effects of E. prostrata as the antimicrobials and bioactive compounds for medicinal usages.


Keyword:     Eclipta prostrata Compositae Bioactive triterpenoids Antimicrobials Antioxidants Cytotoxic activity.

Citation:

Rungrot Cherdtrakulkiat, Somchai Boonpangrak, Ratchanok Pingaew Supaluk Prachayasittikul, Somsak Ruchirawat and Virapong Prachayasittikul. Bioactive triterpenoids, antimicrobial, antioxidant and cytotoxic activities of Eclipta prostrata Linn. J App Pharm Sci, 2015; 5 (03): 046-050.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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