Research Article | Volume: 5, Issue: 11, November, 2015

Synthesis of barbituric acid derivatives using microwave irradiation method and in vitro evaluation of antimicrobial and cytotoxic activity

M. A. Sattar Mst. Khodeza Khatun Rafiquel Islam Md. Hossain Sohrab Sharif M. Al-Reza   

Open Access   

Published:  Nov 27, 2015

DOI: 10.7324/JAPS.2015.501106
Abstract

The research work was involved in rapid and efficient procedure for the attachment of barbituric acid with arylidene acetophenone under microwave irradiation (MWI) and conventional heating. The result showed that the time was reduced from the conventional 24 hours to 5-10 minutes. In conventional heating, the yield of the compounds 2a-2e were very poor (75-81%), but in MW methods the yields were observed 96.48-98% which was comparatively too high. The structures of the compounds were characterized by FT-IR, 1H-NMR spectral data. The antimicrobial and cytotoxic activities of the synthesized compounds were also investigated. Staphylococcus aureus, Bacillus megaterium, Escherichia coli and Pseudomonas aeruginosa revealed the zone of inhibition were 6-12 mm where sample concentration was 100 μg/disc. However, cytotoxic analysis, the mortality 47-95% were appeared when sample concentration were 0.78-25 (μg/ml) and more than 50 (μg/ml) concentration showed 100% mortality. The presence of a reactive and unsaturated ketone function in synthesized compounds was found to be responsible for their potential antimicrobial and cytotoxic activity.


Keyword:     Microwave irradiation (MWI) Barbituric acid derivatives Arylidene acetophenone Antimicrobial and Cytotoxic activity.


Citation:

M. A. Sattar, Mst. Khodeza Khatun, Rafiquel Islam, Md. Hossain Sohrab, Sharif M. Al-Reza. Synthesis of barbituric acid derivatives using microwave irradiation method and in vitro evaluation of antimicrobial and cytotoxic activity. J App Pharm Sci, 2015; 5 (11): 038-042.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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