Research Article | Volume: 5, Issue: 11, November, 2015

Production and optimization of antibacterial metabolites from endophytic fungi Nigrospora sp. ML#3

Kamini Sandey Ravindra Prasad Aharwal Suneel Kumar Sardul Singh Sandhu   

Open Access   

Published:  Nov 27, 2015

DOI: 10.7324/JAPS.2015.501105

Ailanthus excelsa Roxb. is one of the most important plant which has a specific place in Ayurveda and phytotherapy. The tribal people generally used this plant for anthelminthic, anti-fertility, rejuvenation and anti-malarial against Plasmodium falciparum. In the present study total four endophytic fungi were isolated from the leaves of medicinal plant A. excelsa for the production of antibacterial bioactive compounds against five pathogenic bacterial strains. Various cultural conditions like media, pH, temperature and quarantine period was also optimized for the maximum production of antibacterial bioactive compounds from the potent fungus. After each optimizing step, the extracts were tested for antibacterial activity by agar well diffusion method and the best condition was selected for further process.

Keyword:     Endophytic fungi Bioactive compound Optimization Antibacterial activity.


Kamini Sandey, Ravindra Prasad Aharwal, Suneel Kumar, Sardul Singh Sandhu. Production and optimization of Antibacterial metabolites from endophytic fungi Nigrospora sp.ML#3. J App Pharm Sci, 2015; 5 (11): 031-037.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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