Research Article | Volume: 3, Issue: 6, June, 2013

Antifungal Activity of extracts from two Ouratea species on Candida albicans

Marcelo Francisco de Araújoa c Francisco Eduardo Aragão Catunda Júniora d M. Gabriela Alvarezb Edgardo N. Durantinib Mário Geraldo de Carvalhoa   

Open Access   

Published:  Jun 27, 2013

DOI: 10.7324/JAPS.2013.3625
Abstract

Plants are invaluable sources of pharmaceutical products and Brazil, in particular, has yielded an incredible array of plant and animal products that have drawn the attention of ethnopharmacologists from around the world. Ouratea is a genus of tropical plants within the Ochnaceae. Ouratea is widespread throughtout the tropics, with species in Costa Rica, Brazil, Jamaica, and Kenya. The search for compounds with antimicrobial activity is urgent and indispensable for the treatment of infectious diseases caused by microorganisms resistant to traditional antimicrobial drugs. A screening was conducted with organic extracts from two species, from roots and leaves of Ouratea hexasperma var. planchonii Engl. and leaves and branches of Ouratea parviflora Engl., to identify plant extracts with antifungal properties against Candida albicans. Initially, minimal inhibitory concentrations (MICs) were determined in C. albicans cellular suspension in Sabouraud medium, in a range of 0.060-3.0 mg/ml. Fractions OHRMWE (Ethyl acetate fraction) and OHLMWB (Buthanol fraction) obtained by solvents partition of methanol:water extract from Ouratea hexasperma with ethyl acetate from the roots and n-butanol from the leaves, respectively, showed a higher antifungal activity. The antifungal activity of these extracts was also compared in growth delay of C. albicans cultures.


Keyword:     Antifungal activity Ouratea Ochnaceae Candida albicans.


Citation:

Marcelo Francisco de Araújo, Francisco Eduardo Aragão Catunda Júnior, M. Gabriela Alvarez, Edgardo N. Durantini, Mário Geraldo de Carvalho., Antifungal Activity of extracts from two Ouratea species on Candida albicans. J App Pharm Sci. 2013; 3 (06): 152- 155.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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