Research Article | Volume: 3, Issue: 6, June, 2013
Research Article | Volume: 3, Issue: 6, June, 2013
The key target of this review is to compare the efficacies of the different adjuncts and methods used in the management of benzodiazepine dependence (tolerance and withdrawal) and poisoning. A systemic review of randomized controlled trials was carried out to determine which method of adjuvant therapy can be best used to overcome the withdrawal symptoms exhibited during benzodiazepine discontinuation. In addition, different tapering methods employed have also been presented in this review. Zolpidem in combination with cognitive behavioural therapy with a parallel gradual taper after conversion to long half-life Benzodiazepine seems to be a promising method among the several analysed. Finally the efficacies of the two available methods to combat benzodiazepine toxicity, namely flumazenil and naloxone have been discussed and compared.
Mohammad Shohel, Shoaib-Ul-Islam, Rasiqh Wadud, Zaki Farhad Habib, Farjana Malik, Sanjana Kabir and Hasan Mahmud Reza., Management of Benzodiazepine Dependence and Toxicity. J App Pharm Sci, 2013; 3 (06): 146-151.
Year
Month
Biochemical and ultra-structural studies of the effect of alprazolam as an anxiolytic drug on the cerebellum of adult male mice
Pharmacognostical standardization and toxicity profile of the methanolic leaf extract of Plectranthus amboinicus (Lour) Spreng
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