Research Article | Volume: 3, Issue: 6, June, 2013

Management of Benzodiazepine Dependence and Toxicity

Mohammad Shohel Shoaib-Ul-Islam Rasiqh Wadud Zaki Farhad Habib Farjana Malik Sanjana Kabir and Hasan Mahmud Reza   

Open Access   

Published:  Jun 27, 2013

DOI: 10.7324/JAPS.2013.3624

The key target of this review is to compare the efficacies of the different adjuncts and methods used in the management of benzodiazepine dependence (tolerance and withdrawal) and poisoning. A systemic review of randomized controlled trials was carried out to determine which method of adjuvant therapy can be best used to overcome the withdrawal symptoms exhibited during benzodiazepine discontinuation. In addition, different tapering methods employed have also been presented in this review. Zolpidem in combination with cognitive behavioural therapy with a parallel gradual taper after conversion to long half-life Benzodiazepine seems to be a promising method among the several analysed. Finally the efficacies of the two available methods to combat benzodiazepine toxicity, namely flumazenil and naloxone have been discussed and compared.

Keyword:     Benzodiazepine toxicity tapering withdrawal sympt


Mohammad Shohel, Shoaib-Ul-Islam, Rasiqh Wadud, Zaki Farhad Habib, Farjana Malik, Sanjana Kabir and Hasan Mahmud Reza., Management of Benzodiazepine Dependence and Toxicity. J App Pharm Sci, 2013; 3 (06): 146-151.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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