Research Article | Volume : 1 Issue : 4, June 2011

A validated stability indicating HPLC method for the determination of Valsartan in tablet dosage forms

Della Grace Thomas Parambi, Molly Mathew,  V.Ganesan   
Della Grace Thomas Parambi1,Molly Mathew2, V.Ganesan3

1Dept.of Pharmaceutical Analysis, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham University, Kochi, India. Ph.D scholar of Salem Vinayaka missions University.

2Principal, Malik Deenar College of Pharmacy, Kasaragod, India.

3Principal,Erode college of Pharmacy,Erode, India.

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Abstract

A simple, specific, rapid, precise and robust HPLC method has been developed for the quantitation of valsartan in tablet dosage form on a C18 column (250 x 4.6 mm) using a mobile phase consisting of ammonium dihydrogen phosphate buffer : methanol (33.5:66.5) adjusted to pH 3 with formic acid at a flow rate of 1.0 ml/min and detection at 265 nm. The retention time of valsartan was found to be at 11.9 min. The validation of above method was also done. Percentage label claim of the tablet formulations were found to be 100.8%. So the proposed method provides a faster and cost effective quality control tool for routine analysis of valsartan from formulations.


Keyword:     Valsartan HPLC ammonium dihydrogen phosphate buffer methanol validation.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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