Research Article | Volume : 2 Issue : 5, May 2012

Simultaneous determination of pioglitazone and glimepiride in their pharmaceutical formulations

Mamdouh R. Rezk,  Safa#;a M. Riad,  Ghada Y. Mahmoud,  Abdel-Aziz El Bayoumi Abdel Aleem   
Mamdouh R. Rezk, Safa'a M. Riad, Ghada Y. Mahmoud, Abdel-Aziz El Bayoumi Abdel Aleem

Analytical Chemistry Department, Faculty of Pharmacy-Cairo University, Kasr El-Aini Street, ET11562 Cairo, Egypt.

Open Access    DOI: 10.7324/JAPS.2012.2544

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Abstract

Four sensitive and precise spectrophotometric methods were developed and validated for the simultaneous determination of pioglitazone hydrochloride (PGZ) and glimepiride (GLM) in their pharmaceutical formulations. Among the methods adopted were direct absorbance, firstderivative (1D), second-derivative (2D) and first-derivative of ratio spectra (1DD). The selectivity of the proposed methods was checked using laboratory prepared mixtures. The proposed methods were successfully applied to the analysis of GLM and PGZ in their mixture and in pharmaceutical dosage forms without interference from other additives.


Keyword:     Derivative'ratioDerivative spectrophotometry Glimepiride Pioglitazone

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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