Research Article | Volume: 2 Issue: 11, November, 2012

Derivative Spectrophotometric Methods for the Determination of Zolpidem Tartrate in Tablets

M. Mathrusri Annapurna B. Swathi M. Siri Chandra and K. Tulasi   

Open Access    DOI: 10.7324/JAPS.2012.21117

Abstract

Two simple, precise and accurate first derivative spectrophotometric methods were developed for the determination of Zolpidem Tartrate in pharmaceutical formulations in phosphate buffer pH 6.8 and acetate buffer pH 4.0. Beer’s law was obeyed over the concentration range 0.5-20 μg/ml in both phosphate buffer (pH 6.8) (Method A) and acetate buffer (pH 4.0) (Method B). The regression equations were found to be y = 0.101x+0.012 (r2 = 0.999) and y = 0.064x+0.009 (r2 = 0.999) in Method A and B respectively. The % RSD in precision studies was found to be 0.28-0.69 (Intra-day) and 0.31-0.73 (Inter-day) for Method A and 0.25-0.82 (Intra-day) and 0.26-0.57 (Inter-day) for Method B respectively. The % RSD in accuracy studies was also found to be 0.14-0.19 (Method A) and 0.18-0.23 (Method B) with percentage recovery 98.67-99.78 and 98.56-99.83 Method A and B respectively.


Keyword:     Zolpidem tartrate Buffers Derivative spectrophotometry Validation.


Citation:

M. Mathrusri Annapurna, B. Swathi, M. Siri Chandra and K. Tulasi, Derivative Spectrophotometric Methods for the Determination of Zolpidem Tartrate in Tablets. J App Pharm Sci. 2012; 2 (11): 096-099.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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