Research Article | Volume: 8, Issue: 7, July, 2018

Design and Evaluation of Zolpidem Tartrate Matrix Tablets for Extended Release Using Natural Gums and HPMC K100M

Siramsetti Dhanalakshmi Srinivasa Rao Baratam   

Open Access   

Published:  Jul 30, 2018

DOI: 10.7324/JAPS.2018.8712
Abstract

Zolpidem tartrate is a nonbenzodiazepine compound of sedative and hypnotic category used for the treatment of insomnia having a short half-life. Pre-compression parameters were evaluated. The tablets were evaluated for post-compression parameters such as thickness, hardness, average weight, friability and In vitro release studies. No interactions were observed between zolpidem tartrate and excipients from the Fourier transform infrared spectroscopy. The present research work was successful in improving the efficacy of zolpidem tartrate oral therapy as the drug release was extended for twelve hours thus reducing dosing frequency thereby improving patient compliance. The study also revealed the applicability of HPMC K100M, guar gum, and xanthum gum as rate-controlling polymers in matrix tablets. It may be concluded from the study that, formulation F7 (containing 10 mg of xanthum gum) has shown zolpidem tartrate release over a period of 12 h.


Keyword:     Zolpidem tartrate Natural gums HPMC K100M matrix tablets and direct compression.


Citation:

Dhanalakshmi S, Baratam SR. Design and Evaluation of Zolpidem Tartrate Matrix Tablets for Extended Release Using Natural Gums and HPMC K100M. J App Pharm Sci, 2018; 8(07): 072-077.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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