Research Article | Volume: 3, Issue: 3, March, 2013
Research Article | Volume: 3, Issue: 3, March, 2013
Two simple, fast, environmental friendly and reliable spectrophotometric methods were developed for determination of tapentadol hydrochloride in bulk and synthetic mixture containing the possible excipients. The first method is based on measuring the first derivative values of aqueous solution of the drug at 228 nm (method I) and the second method based on measuring the second derivative values at 235 nm (method II). Calibration graphs constructed at their wavelengths of determination were linear in the concentration range of tapentadol 5-60 μg.ml-1 for both methods. The proposed methods have been extensively validated as per ICH guidelines. The developed spectrophotometric methods in this study are simple, accurate, precise, specific and reproducible and can be directly applied to pharmaceutical dosage form.
Mokhtar M. Mobrouk, Hamed M. El-Fatatry, Sherin F. Hammad, Aya A. Mohamed., Spectrophotometric Methods for Determination of Tapentadol Hydrochloride . J App Pharm Sci. 2013; 3 (03): 122-125.
Year
Month
Method Development for Quantification of Donor-Acceptor Complexes of Alverine Citrate and Tapentadol by Visible Spectrophotometry
Derivative Spectrophotometric Methods for the Determination of Zolpidem Tartrate in Tablets
A Validated Comparitative LC and Ratio First Derivative Spectrophotometric Method for the Simultaneous Determination of Levocetrizine dihydrochloride and Montelukast sodium in Bulk and Pharmaceutical dosage forms