Research Article | Volume: 3, Issue: 3, March, 2013

Spectrophotometric Methods for Determination of Tapentadol Hydrochloride

Mokhtar M. Mobrouk Hamed M. El-Fatatry Sherin F. Hammad Aya A. Mohamed   

Open Access   

Published:  Mar 28, 2013

DOI: 10.7324/JAPS.2013.30324

Two simple, fast, environmental friendly and reliable spectrophotometric methods were developed for determination of tapentadol hydrochloride in bulk and synthetic mixture containing the possible excipients. The first method is based on measuring the first derivative values of aqueous solution of the drug at 228 nm (method I) and the second method based on measuring the second derivative values at 235 nm (method II). Calibration graphs constructed at their wavelengths of determination were linear in the concentration range of tapentadol 5-60 μ for both methods. The proposed methods have been extensively validated as per ICH guidelines. The developed spectrophotometric methods in this study are simple, accurate, precise, specific and reproducible and can be directly applied to pharmaceutical dosage form.

Keyword:     Tapentadol Derivative spectrophotometry First deri


Mokhtar M. Mobrouk, Hamed M. El-Fatatry, Sherin F. Hammad, Aya A. Mohamed., Spectrophotometric Methods for Determination of Tapentadol Hydrochloride . J App Pharm Sci. 2013; 3 (03): 122-125.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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