Cytotoxic and antioxidant activities of flavonoids and diterpenoids from Macaranga involucrata (Roxb.) Baill

Alifia Muharram Diah Ayu Rachmawati Shola Mardhiyyah Tjitjik Srie Tjahjandarie Ratih Dewi Saputri Norizan Ahmat Mulyadi Tanjung   

Open Access   

Published:  Jan 10, 2023

DOI: 10.7324/JAPS.2023.101645

Two flavonols, macagigantin (1) and brussoflavonol E (2), and two diterpenoids, deheiculatin C (3) and poilaneic acid (4), were obtained from Macaranga involucrata (Roxb.) Baill. leaves. Their structures were fully detailed on high-resolution electrospray mass spectra, 1D NMR (1H, 13C), and 2D NMR (heteronuclear multiple quantum coherence, heteronuclear multiple bond coherence) spectra. The cytotoxic and antioxidant activities of compounds 1–4 were evaluated in murine leukaemia cancer cells (P-388) and DPPH radical assays, respectively. Compounds 1–3 showed moderate activity against P-388 cells with IC50 values of 26.3, 12.8, and 21.2 μM, respectively. Compounds 1–2 showed high activity against DPPH radical with IC50 values of 332.1 and 125.6 μM, respectively.

Keyword:     Macaranga involucrata flavonoid diterpenoid cytotoxic antioxidant


Muharram A, Rachmawati DA, Mardhiyyah S, Tjahjandarie TS, Saputri RD, Ahmat N, Tanjung M. Cytotoxic and antioxidant activities of flavonoids and diterpenoids from Macaranga involucrata (Roxb.) Baill. J Appl Pharm Sci, 2023.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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