Research Article | Volume: 8, Issue: 11, November, 2018

Pharmacological evaluation of ethnomedicinal Glycosmis pentaphylla Lour. as antidiabetic, antioxidant and cytotoxic agent

Mohammad Oliur Rahman,  Mohammad Badiur Rahman,  Shah Alam Siddiqui,  Mohammad Abul Hassan,  Mohammad Abdur Rashid   
Mohammad Oliur Rahman1, Mohammad Badiur Rahman1, Shah Alam Siddiqui2, Mohammad Abul Hassan1, Mohammad Abdur Rashid3

1Department of Botany, University of Dhaka, Dhaka, Bangladesh.

2Department of Applied Chemistry and Chemical Engineering, Islamic University, Kushtia, Bangladesh.

3Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka 1000, Bangladesh.

Open Access   

Published:  Nov 30, 2018

DOI: 10.7324/JAPS.2018.81112
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Abstract

In this study, an ethnomedicinal plant Glycosmis pentaphylla Lour. has been investigated for its pharmacological potential including antidiabetic, antioxidant, and cytotoxic activities. In the investigation of antidiabetic activity, diabetic induced rats were received methanol extract repeatedly for consecutive 3 weeks. This treatment with the extracts resulted in a reduction of the blood glucose level to 33.82%, 24.38%, and 9.59% after 7, 14, and 21 days of treatment, respectively. In this case, statistically significant blood glucose lowering potential of methanol leaf extract at a dose of 250 mg/kg body weight (bw) was found. In 2,2-diphenyl-1-picrylhydrazyl radical scavenging assessment, moderate antioxidant activity was observed for crude methanol extract with an IC50 value of 46.75 μg/ml. In brine shrimp lethality evaluation, the methanol extract showed significant cytotoxicity with an LC50 value of 22.55 μg/ml. Our study testifies that methanol extract of Glycosmis pentaphylla has promising pharmacological activities and explored these species as a potential source of active secondary metabolites for pharmaceutical and agrochemical industries.


Keyword:     Antidiabetic DPPH brine shrimp lethality cytotoxicity Glycosmis pentaphylla.

Citation:

Rahman MO, Rahman MB, Siddiqui SA, Hassan MA, Rashid MA. Pharmacological evaluation of ethnomedicinal Glycosmis pentaphylla Lour. as antidiabetic, antioxidant and cytotoxic agent. J App Pharm Sci, 2018; 8(11): 080–086.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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