Research Article | Volume: 8, Issue: 1, January, 2018

Formulation and Penetration Enhancement Activity of Sticks Containing Caffeine

Raditya Iswandana Whinanda Chalista Eme Stepani Sitepu   

Open Access   

Published:  Jan 28, 2018

DOI: 10.7324/JAPS.2018.8107

Caffeine is a methylxanthine alkaloid that has been widely used in cosmetic products as anti-cellulite. Caffeine has a hydrophilic character. Thus it has difficulty in penetrating the lipid layer of the skin. This study aimed to formu¬late sticks containing emulsion and microemulsion caffeine (control stick), caffeine emulsions (emulsion stick), and caffeine microemulsion (microemulsion stick) and compare the penetration between them. Caffeine was made in the form of water in oil emulsions and microemulsion then form into sticks-shaped with the lipophilic component. All sticks were physically and chemically evaluated. The penetration of caffeine through Sprague-Dawley rat skin using Franz Diffusion Cell were tested for 12 hours. The penetration result of caffeine from control stick, emulsion stick, and microemulsion stick were 306.42 ± 34.92 μg/cm2, 927.75 ± 57.38 μg/cm2, and 2408.68 ± 81.65 μg/cm2 respec¬tively, with percentage 5.90 ± 0.67%, 12.76 ± 0.78%, and 35.23 ± 1.19%. Physical and chemical stability tests were performed for eight weeks at room temperature (29 ± 2°C), cold temperature (4 ± 2°C), and hot temperature (40 ± 2°C). Microemulsion stick delivered the highest cumulative amount of caffeine in penetration test for 12 hours, followed by emulsion stick and control stick. Also, all sticks showed physical and chemical relatively stable.

Keyword:     Caffeine emulsion microemulsion penetration stick.


Iswandana R, Chalista W, Sitepu ES. Formulation and Penetration Enhancement Activity of Sticks Containing Caffeine. J App Pharm Sci, 2018; 8 (01): 043-049.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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