Research Article | Volume: 7, Issue: 3, March, 2017

The effect of Oxalis corniculata extract against the behavioral changes induced by 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mice

K. Aruna P. Devi Raja Rajeswari S. Raja Sankar   

Open Access   

Published:  Mar 30, 2017

DOI: 10.7324/JAPS.2017.70324

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the development of rigidity, resting tremors and postural instability. Recently, the focus of PD’s treatment has shifted towards herbal medicines. The aim of the study was to evaluate neuroprotective effect of alcoholic extract of Oxalis corniculata (Oxalidaceae), via the analysis of behavioral features in MPTP (1-methyl,4- phenyl-1,2,3,6-tetra hydro pyridine) mouse model. Behavioral studies were performed by the actophotometer, elevated plus maze, rotarod, hole board, step down and step through tests. Treatment with O. corniculata reversed the alterations in locomotor and muscle coordination in MPTP induced Parkinsonic mouse. The results achieved in this study reveal that different doses of O. corniculata increased memory retention and retrieval significantly. Memory retention and retrieval enhancement by O. corniculata extract could be due to the presence of antioxidants such as flavonoids, coumarins, tocopherols and phenolic acids and their power in scavenge reactive oxygen species.

Keyword:     Behaviour MPTP Oxalis corniculata Parkinson’s disease.


Aruna K, Rajeswari PDR, Sankar SR. The effect of Oxalis corniculata extract against the behavioural changes induced by 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mice. J App Pharm Sci, 2017; 7 (03): 148-153.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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