Research Article | Volume: 3, Issue: 10, October, 2013

Aphrodisiac Effect of Ethanol Extract of Piliostigma thonningii Leaf on Male Albino Wistar Rats

Dasofunjo K; Asuk A.A; Ezugwu H.C; Nwodo O.F.C.Olatunji T.L   

Open Access   

Published:  Oct 31, 2013

DOI: 10.7324/JAPS.2013.31023

In an attempt to evaluate the acclaimed aphrodisiac activity of ethanol leaf extract of Piliostigma thoningii, twenty (20) male wistar albino rats were weighed and grouped into four study groups (A-D) of five animals each. Rats in group A (control) were administered with 1ml of distilled water orally while those in groups B, C, and D were given same volume orally, corresponding to 50, 100, and 200 mg/kg body weight of the extract respectively for 21 days. Sexual behaviour parameters were monitored in the male rats for 3 days after administration by pairing with a receptive female (1:1). The male serum testosterone concentration was also determined. Cage side observation on the animals revealed prospective behaviours by the receptive female rats and pre- copulatory behaviours by the extract-treated male rats. The extract at 50, 100, and 200 mg/kg body weight significantly (P < 0.05) increased the frequencies of mount and intromission. In addition, the ejaculation latency was significantly (P < 0.05) prolonged. The latencies of mount and intromission were reduced signifi-cantly (P<0.05) whereas ejaculation frequency increased. The extract also reduced the post- ejaculatory interval of the wistar albino rats. Computed percentages of index of libido, mounted, intromitted, ejaculated and copulatory efficiency were higher in the extract- treated animals than the control whereas the intercopulatory interval decreased significantly. The extract also significantly (P<0.05) increased the serum testosterone content of the animals. Data from this study suggest that the ethanol extract of Piliostigma thonningii leaf enhanced sexual behaviour in male rats.

Keyword:     Aphrodisiac sexual behaviour antioxidant antimicrobial and anti-nutrients.


Dasofunjo K, Asuk A.A, Ezugwu H.C, Nwodo O.F.C., Olatunji T.L. Aphrodisiac Effect of Ethanol Extract of Piliostigma thonningii Leaf on Male Albino Wistar Rats. J App Pharm Sci, 2013, 3 (10): 130-135.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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