Research Article | Volume: 6, Issue: 11, November, 2016

Antioxidant Properties and Electrochemical Behavior of some Acetyl Salicylic Acid Derivatives

Jyothi Poojaria Dhanya Sunila Pooja R Kamatha K. Anandab D. P. Kiranb   

Open Access   

Published:  Nov 29, 2016

DOI: 10.7324/JAPS.2016.601126
Abstract

Antioxidants are frequently used in several dietary supplements and have been probed for their significant role in the prevention of diseases like cancer or coronary heart disease. Acetyl salicylic acid has grabbed substantial attention due to their ability in impeding oxidative stress. In the present study, nine new salicylic acid derivatives: 5-(2-hydroxyphenyl-5-substituted)-1,3,4-oxadiazole-2(3H)-thiones, N-(2,5-dimethyl-1H-pyrrol-1-yl)-2-hydroxy-5-substituted benzamides, 2-hydroxy-5-substituted-N'-[1-(2-oxo-2substituted-chromen-3-yl)ethylidene] benzohydrazides and Hg (II) complex of N'-[(1Z)-1-(6-bromo-2-oxo-2H-chromen-3-yl) ethylidene]-2-hydroxybenzohydrazide have been synthesized and characterized in the light of advanced spectral techniques. The antioxidant properties of these compounds were investigated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) spectrometric assay and compared with the results of cyclic voltammetry studies. The redox properties shown by the active molecule using cyclic voltammetry correlated well with the biochemical study.


Keyword:     Salicylic acid antioxidant cyclic voltammetry redox potential.


Citation:

Poojari J, Sunil D, Kamath PR, Kulal A, Puttanna KD. Antioxidant Properties and Electrochemical Behavior of some Acetyl Salicylic Acid Derivatives. J App Pharm Sci, 2016; 6 (11): 165-171.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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