Research Article | Volume: 4, Issue: 6, June, 2014

Anti-Inflammatory Activities of Methanol Leaf Extract of Bridelia micrantha (Hochst) Baill. (Euphorbiaceae) in Wistar Rats

Nwaehujor Chinaka O Igile Godwin O Ode Julius O and Udegbunam Rita I   

Open Access   

Published:  Jun 28, 2014

DOI: 10.7324/JAPS.2014.40610

Aerial parts of Bridelia micrantha, a semi-deciduous tree are widely used in African traditional medical practice in the treatment of painful inflammatory conditions of the joints. This study evaluated the anti-inflammatory activities of the methanol leaf extract of Bridelia micrantha using acute, sub-acute and chronic models of inflammation in Wistar rats. In the carrageenan-induced acute inflammation model, 400 mg/kg of extract produced 71.79 % edema inhibition while 200 mg/kg of the extract produced 55.13 % inhibition relative to 56.41 % inhibition of the rat paw edema with 200 mg/kg of Acetylsalicylic Acid (ASA) within 5 h. In the histamine-induced rat paw edema model, the extract exhibited 72.97 % protection at 400 mg/kg compared to 83.33 % edema inhibition with phenylbutazone (100 mg/kg) after 6 h. In the sub-acute model using formaldehyde-induced paw edema, 400 mg/kg of extract showed 59.77 % (0.35±0.03) inhibition after 24 h, while 54.02 % inhibition was produced by 200 mg/kg of extract and 200 mg/kg of ASA produced 56.32 % (0.38±0.04) inhibition when compared with the negative control group (0.87±0.05). In the cotton pellet-induced granuloma test, 400 mg/kg of extract gave 52.55 % (40.57±1.3) protection, while 200 mg/kg extract gave 47.25 % protection and 200 mg/kg ASA gave 49.38 % (43.25±1.8) when compared with normal saline treated group (85.5±3.2) after 7 days. The results obtained in this study showed that Bridelia micrantha leaf extract exhibited potent anti-inflammatory activities thus authenticating its acclaimed anti-inflammatory efficacy. It was concluded that the extract of Bridelia micrantha may be a potential anti-inflammatory agent in alleviating edema associated with arthritis and musculo-skeletal pains in humans.

Keyword:     Edema Inflammation Bridelia Micrantha Acetylsalicylic Acid Phenylbutazone.


Nwaehujor Chinaka O, Igile Godwin O, Ode Julius O. and Udegbunam Rita I. Anti-Inflammatory Activities of Methanol Leaf Extract of Bridelia micrantha (Hochst) Baill. (Euphorbiaceae) In Wistar Rats. J App Pharm Sci, 2014; 4 (06): 068-073.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

HTML Full Text


Article Metrics
897 Absract views 80 Absract Downloads 977 Total
Related Search

By author names