Research Article | Volume: 6, Issue: 6, June, 2016

Attenuation of Neuronal Damage by Gymnemic acid in Experimentally Induced Cerebral Ischemia in Rats

Kiran P. Narkhede Anandrao R. Kulkarni Chetan Savant   

Open Access   

Published:  Jun 28, 2016

DOI: 10.7324/JAPS.2016.60620
Abstract

Gymnemic acid is obtained from the natural resource and has got antioxidant property, was investigated for the possible neuroprotective effect in experimentally induced cerebral ischemic rats. Carotid arteries clamped with the help of aneurysm clips to produce cerebral ischemia, the clips were removed from the arteries to allow the reflow of the blood through carotid arteries. It was observed that lipid peroxidation was increased significantly after bilateral common carotid artery occlusion. Brain endogenous antioxidant GSH and total protein levels were low. Administration of gymnemic acid in a dose of 250 mg/kg and 500 mg/kg b.w orally showed promising neuroprotective effect by reducing cerebral infarct size as well as improved all antioxidant levels showing activity against oxidative stress.


Keyword:     Gymnemic acid BCCAO neuroprotective oxidative stress acetyl cholinesterase.


Citation:

Narkhede KP, Kulkarni AR, Savant C. Attenuation of Neuronal Damage by Gymnemic acid in Experimentally Induced Cerebral Ischemia in Rats. J App Pharm Sci, 2016; 6 (06): 113-118.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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