Review Article | Volume: 2 Issue: 12, December, 2012

Gymnema sylvestre: An Alternative Therapeutic Agent for Management of Diabetes

Gulab S. Thakur Rohit Sharma Bhagwan S. Sanodiya Mukeshwar Pandey GBKS Prasad and Prakash S. Bisen   

Open Access    DOI: 10.7324/JAPS.2012.21201

Abstract

Gymnema sylvestre (Asclepiadaceae) also known as 'gurmar' or 'sugar destroyer' is a woody, climbing traditional medicinal herb which has many therapeutic applications in Ayurvedic system of medicine. It is used for lowering serum cholesterol, triglycerides and blood glucose level (hypoglycemic or antihyperglycemic), hypolipidaemic, weight loss, stomach ailments, constipation, water retention and liver diseases, either high or low blood pressure, tachycardia or arrhythmias, and used as aperitive, purgative, in eye troubles, anti-inflammatory, smooth muscle relaxant, prevention of dental caries, cataract and as anticancer-cytotoxic agent. Its flowers, leaves, and fruits contains alkaloids, flavones, saponins, sapogenins, anthraquinones, hentri-acontane, pentatriacontane, α and β-chlorophylls, phytin, resins, d-quercitol, tartaric acid, formic acid, butyric acid, lupeol, β-amyrin related glycosides and stigmasterol having main principle bioactive compunds viz. gymnemic acids, gymnemasides, gymnemagenin, gurmarin, gymnemosides, gymnemanol, gymnemasins, gypenoside, and conduritol which act as therapeutic agent and play vital role in many therapeutic applications. Gymnemic acids are thought to be responsible for its antidiabetic activity and it is the major component of an extract shown to stimulate insulin release from the pancreas. Another anti-sweet agent gumarin is utilized as a pharmacological tool in the study of sweet-taste transduction. The commercial exploitation of this plant and their secondary metabolites are some of the major prospective of this rare medicinal herb. The focus of the present review is to achieve the potential of therapeutic value of this herb and mechanism and action of their secondary metabolites.


Keyword:     Gymnemic acidobesitygumarintherapeutic agentantidiabetic


Citation:

Gulab S. Thakur, Rohit Sharma, Bhagwan S. Sanodiya, Mukeshwar Pandey, GBKS Prasad and Prakash S. Bisen., Gymnema sylvestre: An Alternative Therapeutic Agent for Management of Diabetes. J App Pharm Sci. 2012; 2 (12): 001- 006.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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