Published:  Jan 28, 2013DOI: 10.7324/JAPS.2013.30108
The present investigation was an attempt to study the enhancememt effect of L-carnosine (beta alanyl-l-histidine) on the influence of vaccination on healthy (non-infected) rabbits treated with Schistosoma mansoni egg antigens, cercariae antigens, and worms antigens as protective agents against infection. This study involved individual injection of three Schistosoma mansoni antigens: soluble egg antigen (SEA), cercarial antigen preparation (CAP) and soluble worm antigen preparation (SWAP), in three rabbit groups, respectively. Three other groups each received the same specific antigen in conjunction with the administration of L-carnosine, biochemical parameters including DNA, RNA, DNA/RNA ratio concentrations in addition ATPase, and acetyl cholinesterase activities were measured in liver, heart, kidney and brain in all groups. Elevation in most parameters was observed in the immunized groups. Carnosine treatment of rabbit groups immunized with SEA, CAP and SWAP in comparison to the non-carnosine-treated immunized groups resulted in amelioration the changes of DNA, RNA, ATPase and acetyl cholinesterase activities in most groups. L-carnosine has a beneficial effect in the amelioration of the changes in biochemical parameters as a result of S. mansoni antigen immunization.
Naima Z. Mohamed, Monira A.Abd El Kader, Sanaa A. Ali., Efficacy of L-carnosine against Schistosoma mansoni antigens in liver, heart, kidney and brain rabbits. J App Pharm Sci. 2013; 3 (01): 039-045.
561 Absract views 4 PDF Downloads 565 Total views
Agrobacterium mediated biotransformationAshish Kakkar, Vineet Kumar Verma
Synthesis of Several Novel Symmetrical Amide-Linked Tetra-Benzimidazoles as Promising DNA and/or RNA Binders
Attenuation of Neuronal Damage by Gymnemic acid in Experimentally Induced Cerebral Ischemia in Rats