Research Article | Volume: 6, Issue: 1, January, 2016

Cytotoxic and Antibacterial Evaluation of Coumarins and Chromanone Acid from Calophyllum symingtonianum

Nurul Iman Aminudin Farediah Ahmad Muhammad Taher Razauden Mohamed Zulkifli   

Open Access   

Published:  Jan 26, 2016

DOI: 10.7324/JAPS.2016.600104

Calophyllum symingtonianum is a rare species from the Calophyllum genus that belongs to the Guttiferae family. Calophyllum has been recognized as a potential medicinal plant due to its many bioactive phytochemicals especially coumarins and chromanone acids. In this study, the cytotoxic activities against MCF-7 and A-549 and antibacterial activities towards S. aureus, B. subtilis, P. aeruginosa and E. Coli of three coumarins known as inophyllum D, inophyllum H and calanone as well as chromanone acid identified as isocordato-oblongic acid isolated from this plant were evaluated. Inophyllum H exhibited the highest IC50 values against MCF-7 at 25.56 µg/mL and A-549 at 26.41µg/mL. Isocordato-oblongic acid showed moderate antibacterial activity against S. aureus and B. subtilis at 125µg/mL and 62.5µg/mL, respectively. This study suggests C. symingtonianum as a potential plant for cytotoxic and antibacterial phytochemicals.

Keyword:     Calophyllum symingtonianum cytotoxic antibacterial coumarin chromanone acid Guttiferae.


Aminudin NI, Ahmad F, Bakhtiar MT, Zulkifli RM. Cytotoxic and Antibacterial Evaluation of Coumarins and Chromanone Acid from Calophyllum symingtonianum. J App Pharm Sci, 2016; 6 (01): 023-027.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

HTML Full Text


Article Metrics

363 Absract views 20 PDF Downloads 383 Total views

   Abstract      Pdf Download

Related Search

By author names

Citiaion Alert By Google Scholar

Name Required
Email Required Invalid Email Address

Comment required