Short Communication | Volume: 2 Issue: 12, December, 2012

Scopoletin, a coumarin derivative compound isolated from Macaranga gigantifolia Merr

Akhmad Darmawan Soleh Kosela Leonardus B.S. Kardono and Yana M. Syah   

Open Access    DOI: 10.7324/JAPS.2012. 21231

Abstract

Scopoletin (1), a coumarin derivative compound has been isolated from methanol extract of Macaranga gigantifolia Merr. leaves using chromatography methods. Chemical structure determination carried out based on spectroscopic data and compared with a reference. Scopoletin cytotoxicity test using MTT assay method against P-388 murine leukemia cells showed strong cytotoxic activity with IC50 17.42 μg/mL.


Keyword:     Scopoletin Coumarin Derivative Macaranga Gigantifolia Merr.


Citation:

Akhmad Darmawan, Soleh Kosela, Leonardus B.S. Kardono, and Yana M. Syah., Scopoletin, a coumarin derivative compound isolated from Macaranga gigantifolia Merr. J App Pharm Sci. 2012; 2 (12): 175-177.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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