Research Article | Volume: 6, Issue: 1, January, 2016

Cytotoxic and Antibacterial Evaluation of Coumarins and Chromanone Acid from Calophyllum symingtonianum

Nurul Iman Aminudin,  Farediah Ahmad,  Muhammad Taher,  Razauden Mohamed Zulkifli   
Nurul Iman Aminudin1, Farediah Ahmad1, Muhammad Taher2, Razauden Mohamed Zulkifli3

1Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310 Skudai Johor, Malaysia.

2Department of Pharmaceutical Technology, Kulliyyah of Pharmacy, International Islamic University Malaysia, Jalan Sultan Ahmad Shah, Bandar Indera Mahkota, 25200 Kuantan, Pahang, Malaysia.

3Department of Bioscience and Health Sciences, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, 81310 Skudai Johor, Malaysia.

Open Access   

Published:  Jan 26, 2016

DOI: 10.7324/JAPS.2016.600104
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Abstract

Calophyllum symingtonianum is a rare species from the Calophyllum genus that belongs to the Guttiferae family. Calophyllum has been recognized as a potential medicinal plant due to its many bioactive phytochemicals especially coumarins and chromanone acids. In this study, the cytotoxic activities against MCF-7 and A-549 and antibacterial activities towards S. aureus, B. subtilis, P. aeruginosa and E. Coli of three coumarins known as inophyllum D, inophyllum H and calanone as well as chromanone acid identified as isocordato-oblongic acid isolated from this plant were evaluated. Inophyllum H exhibited the highest IC50 values against MCF-7 at 25.56 µg/mL and A-549 at 26.41µg/mL. Isocordato-oblongic acid showed moderate antibacterial activity against S. aureus and B. subtilis at 125µg/mL and 62.5µg/mL, respectively. This study suggests C. symingtonianum as a potential plant for cytotoxic and antibacterial phytochemicals.


Keyword:     Calophyllum symingtonianum cytotoxic antibacterial coumarin chromanone acid Guttiferae.

Citation:

Aminudin NI, Ahmad F, Bakhtiar MT, Zulkifli RM. Cytotoxic and Antibacterial Evaluation of Coumarins and Chromanone Acid from Calophyllum symingtonianum. J App Pharm Sci, 2016; 6 (01): 023-027.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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