Research Article | Volume: 5, Issue: 10, October, 2015

Ruta graveolens and its active constituent rutin protect against diethylnitrosamine-induced nephrotoxicity through modulation of oxidative stress

Ayman M. Mahmoud Rasha R. Ahmed Hanan A. Soliman Marwa Salah   

Open Access   

Published:  Oct 28, 2015

DOI: 10.7324/JAPS.2015.501004
Abstract

The current study was designed to evaluate the possible protective effects of Ruta graveolens (Rue) and its active phenolic constituent rutin against diethylnitrosamine (DEN)-induced nephrotoxicity in rats. A single dose of DEN (200 mg/kg body weight) was intraperitoneally injected. Two-weeks after DEN administration, rats received 0.05 % phenobarbital in drinking water for 12 weeks. Ruta graveolens (50 mg/kg) and rutin (50 mg/kg) were orally administered from the first day of experiment. DEN administration induced kidney injury evidenced by histological alterations as well as significant increase in serum urea (P<0.01), creatinine (P<0.001) and uric acid (P<0.001), and renal lipid peroxidation levels. On the other hand, renal glutathione content and activity of superoxide dismutase, glutathione peroxidase and glutathione-s-transferase were significantly declined. Concomitant supplementation with either R. graveolens extract or rutin markedly alleviated the altered biochemical and histopathological features. In conclusion, the current findings provide evidence that R. graveolens and its active phenolic component rutin could protect against DEN-induced renal damage through abolishment of oxidative stress and potentiation of the antioxidant defense system.


Keyword:     Rue Flavonoids Renal injury Oxidative stress Antioxidants.


Citation:

Ayman M Mahmoud, Rasha R Ahmed, Hanan A Soliman, Marwa Salah. Ruta graveolens and its active constituent rutin protect against diethylnitrosamine-induced nephrotoxicity through modulation of oxidative stress. J App Pharm Sci, 2015; 5 (10): 016-021.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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