Research Article | Volume : 1 Issue : 5, July 2011

Synthesis and in-vitro screening of 3,4-dihydropyrimidin-2(1H)-one derivatives for antihypertensive and calcium channel blocking activity

Hiren M. Marvaniya Palak K. Parikh Dhrubo Jyoti Sen   

Open Access   

Abstract

Pyrimidine plays a significant role among other heterocycles. From the literature survey, in recent years the design of 3,4-dihydropyrimidin-2(1H)-ones nucleus have been attracted for considerable interest because of their therapeutic and pharmacological properties. Pyrimidine nucleus was synthesized by Biginelli reaction. This product was subjected for alkaline ester hydrolysis and these derivatives on treatment with thionyl chloride and substitution by different secondary amines produced final desired compounds. The remaining compounds have been synthesized by above method. The purity of the compounds has been checked by TLC monitoring and the conformation of structure was confirmed by different spectra like UV, IR, NMR, Mass etc. The in-vitro antihypertensive and calcium channel blocking activity have been done by IC50 measurement method with nifedipine as standard.


Keyword:     34-dihydropyrimidin-2(1H)-ones Biginelli reaction Antihypertensive and Calcium channel blocking activity IC50 Nifedipine.


Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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