The Thiadiazole & their derivatives shown the number of pharmacological activity as anti microbial ,anti inflammatory activity, anti tubercular activity, ant diabetic activity, diuretics, anti depressant & cytotoxic activity. these thiadiazole are the heterocyclic compound which contain the five member ring & nitrogen & sulphur. In this paper we mention the recent derivatives of 1,3,4thiadiazole & their activity.
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