Research Article | Volume: 3, Issue: 4, Supplement: 1, May, 2013
Research Article | Volume: 3, Issue: 4, Supplement: 1, May, 2013
This study is an investigation of the physicochemical interaction of Losartan potassium (LST K), an angiotensin-II receptor (type AT1) antagonist, with micelles of triton X, a nonionic surfactant. The effect of micelles on the spectral properties of LSTK was monitored on at pH 7.4 and at room temperature. The spectrum of LST K showed gradual and progressive bathochromic and hypochromic shift in presence of increasing concentrations of triton X 100. The binding constant Kb of LST K to triton X 100 micelles was calculated using the differential absorbance at λ = 225 nm& was found to be 4.13 ± 0.35 ×105 mol-1 L. By using pseudo-phase model, the partition coefficient between the bulk water and Triton X 100 micelles, Kx, was calculated from both differential absorbance Δ A225, Kx = 2.26 ±0.12 x105 mol-1 L. The binding of LST K to Triton X 100 micelles implied a shift in drug acidity constant (Δ pKa = 0.8)
Laila Abdel-Fattah, Amira El-Kosasy, Lobna Abdel-Aziz, Mariam Gaied., Interaction of Losartan potassium with the micelles of Triton X 100. J App Pharm Sci, 2013; 3 (4 Suppl 1): S38-S43.
Year
Month
Development and evaluation of liquid oral controlled release systems for Losartan potassium
Marwa A. Amer, Ebtessam A. Essa, Ahmed A. Donia, Gamal M. El MaghrabyComparison between Microplate Spectrometry and LC/MS Chromato-graphy for Facile Pilot Pharmacokinetics and Biodistribution Studies of Doxorubicin-loaded Nanoparticle Drug Carriers
Applications of Micellar Liquid Chromatography in Bioanalysis: A Review