Review Article | Volume: 4, Issue: 1, January, 2014

Applications of Micellar Liquid Chromatography in Bioanalysis: A Review

Kalyankar T. M. Kulkarni P.D. Wadher S. J. and Pekamwar S. S.   

Open Access   

Published:  Jan 30, 2014

DOI: 10.7324/JAPS.2014.40122

Micellar liquid chromatography (MLC) is one of the very important analytical techniques. It contains mobile phase added with surfactants above its critical micellar concentration and the stationary phase is modified with surfactant monomers. So, micelles alter the solubilising capability of the mobile phase which forms diverse interactions with major implications in retention and selectivity. It is an alternative to conventional reversed phase liquid chromatography. It allows direct injection of physiological fluids, analysis of pharmaceutical compounds, physiological partitioning process. MLC (micelle liquid chromatography) has proved time saving as compared to other analytical technique like HPLC and ion-pairing. Applicability of MLC is increased in the field of bioanalysis. It is used to analyze different samples of drugs in serum, urine, food etc. In this review we have focused on the various examples of use of MLC in bioanalysis. This review also contains basic information about MLC such as micellar mobile phase, stationary phase, surfactants, and fundamental studies such as retention behavior and partition coefficient.

Keyword:     MLC bioanalysis micelles partition coefficient and retention behavior.


Kalyankar T. M., Kulkarni P.D., Wadher S. J. and Pekamwar S. S. Applications of Micellar Liquid Chromatography in Bioanalysis: A Review. J App Pharm Sci, 2014; 4 (01): 128-134.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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