Research Article | Volume: 3, Issue: 3, March, 2013
Research Article | Volume: 3, Issue: 3, March, 2013
The lipid profile studies of garlic, antioxidant vitamins C and E on pefloxacin-induced toxicity in wistar rat was evaluated. Method: One hundred adult wistar rats (120-180), of either sex were randomly selected into five study groups. Each group comprised of 10 pairs (ten males and ten females) were not allowed to mate, with group 1 as control. Group 11 were pefloxacin treated only while group 111 to 1V were pefloxacin treated with either garlic, vitamins C and E. Pefloxacin, garlic vitamin C and E in doses 11.43mg/kg, 4.28mg/kg, 14.29mg/kg body weight in normal saline (vehicle) was administered orally by intubation to male and female of groups 11 to V for 14 days. Control animals received 0.5ml of normal saline. In life observation measurements were taken and at the end of drug, garlic, antioxidant vitamins C and E combined administration animals were sacrificed and tissues obtained for biochemical assessment. Result: Physical signs of toxicity and ameliorating effects of antioxidant vitamins and garlic were also expressed in rats, pefloxacin treatment induced significant (P<0.05) increase in total cholesterol, low density lipoprotein, very low density lipoprotein, triacylglycerol and decrease in high density lipoprotein relative to control but PF exposed and antioxidant vitamins C, E and garlic treated groups produced significant (P
Ukpanukpong, R. U, Eteng, M. U and Dasofunjo, K., Antioxidant interactions of Pefloxacin, garlic, vitamins C and E on lipid profile level of Albino wistar rats. J App Pharm Sci. 2013; 3 (03): 167- 170.
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Edward, K.C., Ohaegbu, C.G.Haematological studies of antioxidant vitamins C, E and garlic on Pefloxacin Induced Toxicity in Wistar Rats