Research Article | Volume: 3, Issue: 1, January, 2013

Haematological studies of antioxidant vitamins C, E and garlic on Pefloxacin Induced Toxicity in Wistar Rats

Ukpanukpong R .U Eteng M.U Dasofunjo K Pekene D.B.J Utu-Baku B. A and Onyeama H.P   

Open Access   

Published:  Jan 28, 2013

DOI: 10.7324/JAPS.2013.30120
Abstract

The Haematological studies of garlic, antioxidant vitamins C and E on pefloxacin-induced toxicity in wistar rat was evaluated. Method: One hundred adult wistar rats (120-180), of either sex were randomly selected into five study groups. Each group comprised of 10 pairs (ten males and ten females) were not allowed to mate, with group 1 as control. Group 11 were pefloxacin treated only while group 111 to 1V were pefloxacin treated with either garlic, vitamins C and E. Pefloxacin, garlic vitamin C and E in doses 11.43mg/kg, 4.28mg/kg, 14.29mg/kg body weight in normal saline (vehicle) was administered orally by intubation to both male and female of groups 11 to V for 14 days. Control animals received 0.5ml of normal saline. In life observation measurements were taken and at the end of drug, garlic, antioxidant vitamins C and E combined administration animals were sacrificed and tissues obtained for biochemical assessment. Result: Physical signs of toxicity and ameliorating effects of antioxidant vitamins and garlic were also expressed in rats, significant (p<0.05) decrease in Hb, PCV, RBC and Total WBC were observed. Conclusion: These results suggest adverse effect of pefloxacin and ameliorating role of garlic, vitamins C and E on wistar rats.


Keyword:     Pefloxacin garlic vitamins C and E body weight hematological and histological.


Citation:

Ukpanukpong, R. U, Eteng, M. U and Pekene, D. B. J., Haematological studies of antioxidant vitamins C, E and garlic on Pefloxacin Induced Toxicity in Wistar Rats. J App Pharm Sci. 2013; 3 (01): 103-107.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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