Research Article | Volume: 2 Issue: 10, October, 2012

Biological activities of [1,2,4] triazolo-[3,4-b],[1,3,4]-thiadiazole-6-yl) (o-tolyamino) methylazetidin-2-one

Harcharan Lal Neeraj Sharma T.P. Agarwal and Nitin Sharma   

Open Access    DOI: 10.7324/JAPS.2012.21021


Synthesis of 4-amino-5-(3-bromophenyl)-4H-1,2,4-triazole-3-thiol (1), 3-(3-bromophenyl) [1,2,4]-triazolo [3,4-b][1,3,4] thiadiazol-6-amine (2), N-substituted benzylidene -3-(3-bromophenyl)-[1,2,4] triazolo-[3,4-b] [1,3,4]-thiadiazole-6-amine (3-7),1-(3-(3-bromophenyl )-[1,2,4 ]triazolo-[3,4-b] [1,3,4]-thiadiazole-6-yl)-4-substitutedphenyl azetidin-2-one (8-12), 3-(3-(3-bromophenyl)-[1,2,4] triazolo-[3,4-b] [1,3,4]-thiadiazole-6-yl)-2-phenylthia zolidin-4-one (13-17), 1-(3-(3-bromophenyl)-[1,2,4]triazolo-[3,4-b], [1,3,4]-thiadiazole-6-yl)-4-substi- tutedphenyl-3-((o-tolyamino)methyl) azetidin-2-one (18-27). Among all the synthesized compounds, Mannich products were found to possess wide spectrum of antibactderial and antifungal activities with lesser potency and among the mannich products, 22 and 26 were found most potent compound of the series.

Keyword:     Triazole derivativesAntibacterial & antifungal activities.


Harcharan Lal, Neeraj Sharma, T.P. Agarwal & Nitin Sharma. Biological activities of [1,2,4]triazolo-[3,4-b],[1,3,4]-thiadiazole-6-yl) (otolyamino)methylazetidin-2-one. J App Pharm Sci. 2012; 2(10): 104-112.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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