Research Article | Volume: 2 Issue: 10, October, 2012

Formulation and evaluation of telmisartan microspheres by emulsion solvent evaporation technique

Sujata D. BansodeVeena S. KastureSarita S. Pawar and Sanjay B. Kasture   

Open Access    DOI: 10.7324/JAPS.2012.21022

Abstract

Microspheres are multi-component system provide constant and prolonged drug release. Furthermore their floating abilities increase gastric residence time. These properties reduce the gastrointestinal toxic effects and dosing frequency and thereby improve the patient compliance. The present study aimed to formulate and evaluate telmisartan microspheres. Emulsion solvent evaporation (ESE) technique was employed for microsphere preparation using different ratios of ethyl cellulose polymer and drug. Prepared microspheres were evaluated for drug entrapment efficiency, micromeritic characters, floating behaviour and in vitro drug release. This revealed polymer drug ratio has influence on drug release.


Keyword:     Microspheretelmisartanethyl celluloseemulsion solvent evaporation.


Citation:

Sujata D. Bansode, Veena S. Kasture, Sarita S. Pawar, Sanjay B. Kasture. Formulation and evaluation of telmisartan microspheres by emulsion solvent evaporation technique. J App Pharm Sci. 2012; 2 (10): 113-116.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

HTML Full Text

Reference

Article Metrics
609 Views 102 Downloads 711 Total

Year

Month

Related Search

By author names